ACS患者外周血中脂肪酸合酶表达及炎症反应程度评估及sEHi的干预效果研究  

Expression of fatty acid synthase and inflammation severity evaluation in peripheral blood of patients with ACS and intervention effect of sEHi

作　　者：王蔚[1] 王越希 钟德超[3] 李丹[3] 陈茂[1] 

机构地区：[1]四川大学华西医院心脏内科,四川成都610041 [2]自贡市第一人民医院肿瘤科,四川自贡643000 [3]自贡市第一人民医院心血管内科,四川自贡643000

出　　处：《海南医学院学报》2016年第6期539-541,544,共4页Journal of Hainan Medical University

基　　金：四川省医学会"施慧达"科研课题(SHD12-01)~~

摘　　要：目的:分析急性冠脉综合征(ACS)患者外周血中脂肪酸合酶表达及炎症反应程度评估及sEHi的干预效果。方法:所有研究对象中急性冠脉综合征患者132例,包括急性ST段抬高性急性梗死(STEMI)患者68例,非ST段抬高性急性冠状动脉综合征(NSTE-ACS)64例,另取在本院接受体检的健康人群78例作为健康对照组,检测3组外周血中脂肪酸合酶表达及炎症反应程度,对比ACS患者接受sEHi干预前后的脂肪酸合酶、炎症因子及血脂水平差异。结果:STEMI组血清FASN水平、CRP、IL-6、IL-12、IL-18、IL-23水平高于NSTE-ACS组及健康对照组(P<0.05);ACS患者接受sEHi干预后的血清FASN水平低于干预前,炎症因子包括CRP、IL-6、IL-12、IL-18、IL-23值也大幅低于干预前(P<0.05);ACS患者的sEHi干预后TC、TG、LDL-C水平低于干预前,HDL-C水平高于干预前(P<0.05)。结论:ACS患者外周血脂肪酸合酶表达及炎症反应程度上升,经sEHi干预后脂肪酸合酶、炎症反应及血脂水平均得到优化,是治疗ACS的有效方式。Objective： To analyze expression of fatty acid synthase and inflammation degree evaluation in peripheral blood of patients with ACS and intervention effect of sEHi. Methods： A total of 132 patients with acute coronary syndrome were enrolled including 68 patients with acute ST segment elevation myocardial infarction （STEMI） and 64 cases of patients with non-ST segment elevation acute coronary syndrome （NSTE-ACS）, 78 cases of healthy subjects who received physical examination in our hospital were selected as healthy control group, fatty acid synthase expression and inflammation degree in peripheral blood of three groups were detected, and differences in levels of fatty acid synthase, inflammatory factors and blood lipid in patients with ACS before and after sEHi intervention were compared. Results.. Serum FASN, CRP, IL-6, IL-12, IL-18and IL-23 levels of STEMI group were higher than those of NSTE-ACS group and healthy control group （P〈0.05）; serum FASN level of patients with ACS after sEHi intervention was lower than that before intervention, and values of inflammatory factors CRP, IL-6, IL-12, IL-18 and IL-23 were also dramatically lower than those before intervention （P〈0.05）; TC, TG and LDL-C levels of patients with ACS after sEHi intervention were lower than those before intervention, and HDL-C levels were higher than those before intervention （P〈0.05）. Conclusion： Fatty acid synthase expression and inflammation degree increase in peripheral blood of patients with ACS, levels of fatty acid synthase, inflammation and blood lipid are optimized after sEHi intervention, and it is an effective way to treat ACS.

关 键 词：急性冠脉综合征(ACS) 脂肪酸合酶 sEHi 炎症反应 

分 类 号：R543[医药卫生—心血管疾病]