血清微量元素及抗氧化能力指标与妊娠期高血压疾病的关系分析  

Relationship between serum trace elements and antioxidant capacity indexes in women of hypertensive disorder complicating pregnancy

作　　者：刘洋[1] 徐梅[1] 蒋英[1] 张雁[2] 

机构地区：[1]江苏省徐州市中心医院妇产科,江苏徐州221009 [2]河北省承德市承德医学院附属医院,河北承德067000

出　　处：《海南医学院学报》2016年第6期574-576,579,共4页Journal of Hainan Medical University

基　　金：承德市科学技术局科技支撑计划项目(201121051)~~

摘　　要：目的:分析血清微量元素及抗氧化能力指标与妊娠期高血压疾病(HDCP)的相关性。方法:选择40例正常健康晚孕孕妇、21例妊娠期高血压孕妇、28例子痫前期轻度孕妇、22例子痫前期重度孕妇,比较各组间血常规及凝血功能差异,同时采用火焰原子吸收光谱法测定受试者全血微量元素水平,检测胎盘绒毛组织氧化应激相关指标水平。结果:HDCP孕妇白细胞、红细胞压积显著高于正常健康孕妇,血小板及纤维蛋白原水平则显著低于正常健康孕妇,凝血酶时间长于正常健康孕妇,血清铜、锌、锰水平显著低于正常健康孕妇,铁则显著高于正常健康孕妇,组间差异均有统计学意义(P均<0.05)。HDCP孕妇胎盘绒毛组织中超氧化物歧化酶(SOD)及谷胱甘肽过氧化物酶(GSH-PX)活力显著小于正常健康孕妇,而人同型半胱氨酸(Hcy)水平则高于正常健康孕妇,组间差异有统计学意义(P均<0.05)。结论:妊娠期高血压孕妇体内微量元素失衡,氧化还原系统平衡失调,要加强妊高征孕妇微量元素、氧化还原相关指标的测定,确保母婴健康。Objective： To analyze the relationship between serum trace elements and antioxidant capacity indexes and Hypertensive Disorder Complicating Pregnancy （HDCP）. Methods： A total of 40 healthy pregnant women , 21 pregnant women with high blood pressure, 28 cases of mild preeclampsia, 22 cases of severe preeclampsia were selected. Routine blood test results, blood coagulation functions were compared between groups. Level of trace elements in whole blood was determined by flame atomic absorption spectrometry, and level of oxidative stress related indicators in the placental villi were also detected. Results; The white blood cells, hematocrit of HDCP pregnant women were significantly higher than healthy pregnant women, platelet and fibrinogen levels were lower than healthy pregnant women, thrombin time was shorter than healthy preg nant women, serum levels of copper, zinc and manganese were significantly lower than healthy pregnant women. But iron was higher than that of healthy pregnant women （P all〈0.05）. The SOD and GSH-PX activity of HDCP pregnant women were significantly weaker than that of healthy pregnant women, while the Hcy level was higher than that of healthy pregnant women （P all〈0.05）. Cornclusion：Trace element imbalance and redox system equilibrium are presented in pregnant women with gestational hypertension indicating determination of the trace elements and redox related indicators of HDCP should be applied to ensure health of maternal and child.

关 键 词：微量元素 抗氧化 妊娠期高血压 

分 类 号：R714.2[医药卫生—妇产科学]