糖尿病肾脏病证候与病机特征回顾性分析  

Retrospective Analysis on Characteristics of Syndrome and Pathogenesis of Diabetic Kidney Disease

作　　者：吴文静[1] 赵进喜[1] 王世东[1] 傅强[1] 张亚欣[1] 宫晴[1] 

机构地区：[1]北京中医药大学东直门医院,北京市东城区海运仓5号100700

出　　处：《中医杂志》2016年第3期216-219,共4页Journal of Traditional Chinese Medicine

基　　金："十五"国家科技攻关计划(2001BA701A13c);"十一五"国家科技支撑计划(2006BAI04A03-2)

摘　　要：目的通过分析临床资料的常见证素,初步总结糖尿病肾脏病(DKD)的基本病机和证候特征。方法回顾性分析"十五"国家科技攻关计划和"十一五"国家科技支撑计划期间DKD临床研究纳入患者入组时中医证候调查表,对患者症状进行证素辨证,运用频数分析方法对不同分期常见证素的分布进行描述性分析。结果共纳入患者544例。其中早期患者152例,临床期肾功能正常患者112例,肾功能不全代偿期患者195例,肾功能不全失代偿期患者85例。早期患者证素分布为:气虚证(71.7%)、阴虚证(66.4%)、阳虚证(50.1%)、血瘀证(48.0%)、痰湿证(45.4%)、湿浊证(25.7%)、血虚证(19.1%);临床期肾功能正常患者证素分布为:气虚证(71.4%)、阴虚证(59.8%)、阳虚证(58.0%)、血瘀证(51.8%)、痰湿证(43.8%)、血虚证(20.5%)、湿浊证(8.0%);临床期肾功能不全代偿患者期证素分布为:气虚证(77.9%)、阳虚证(70.8%)、血瘀证(66.2%)、痰湿证(54.9%)、阴虚证(52.8%)、湿浊证(29.7%)、血虚证(28.2%);临床期肾功能不全失代偿患者期证素分布为:阳虚证(80.0%)、气虚证(71.8%)、血瘀证(62.4%)、阴虚证(52.9%)、痰湿证(48.2%)、血虚证(32.9%)、湿浊证(31.8%)。结论 DKD不同阶段气虚血瘀证普遍存在,气虚血瘀是其基本病机。Objective To make preliminary summary on characteristics of syndrome and pathogenesis of diabetic kidney disease（DKD）by retrospectively analyzing common syndrome elements of clinical data.Methods Chinese medicine syndrome questionnaires of patients participating in the DKD clinical research at enrollment were analyzed retrospectively,which was conducted during the period of the ＂Tenth Five-Year＂national science and technology key problems plan and the ＂Eleventh Five-Year＂national science and technology support plan.Syndrome elements differentiation was made on patients＇ symptoms.Descriptive analysis was made on distribution of common syndrome elements in different stages by the method of frequency analysis.Results Totally 544 patients were included.Among them,152 patients were in the early stage,112 in clinical stage with normal kidney function,195 in renal insufficiency compensation stage,85 in renal insufficiency decompensated stage.The syndrome elements distribution of early stage patients was Qi deficiency syndrome（71.7%）,Yin deficiency syndrome（66.4%）,Yang deficiency syndrome（50.1%）,blood stasis syndrome（48.0%）,phlegm-dampness syndrome（45.4%）,damp pathogen syndrome（25.7%）,blood deficiency syndrome（19.1%）.The syndrome elements distribution of clinical stage patients with normal kidney function was Qi deficiency syndrome（71.4%）,Yin deficiency syndrome（59.8%）,Yang deficiency syndrome（58.0%）,blood stasis syndrome（51.8%）,phlegm-dampness syndrome（43.8%）,blood deficiency syndrome（20.5%）,damp pathogen syndrome（8.0%）.The syndrome elements distribution of renal insufficiency compensation stage patients was Qi deficiency syndrome（77.9%）,Yang deficiency syndrome（70.8%）,blood stasis syndrome（66.2%）,phlegm-dampness syndrome（54.9%）,Yin deficiency syndrome（52.8%）,damp pathogen syndrome（29.7%）,blood deficiency syndrome（28.2%）.The syndrome elements distribution of renal insufficiency decompensated stage patients was Yang deficien

关 键 词：糖尿病肾脏病 病机 证素 气虚血瘀 

分 类 号：R259[医药卫生—中西医结合] R277.5[医药卫生—中医内科学]