非灵长类动物精原干细胞及其多潜能性的研究进展  

Research development of spermatogonial stem cell and their pluripotency in non-primate mammals

作　　者：范翠花[1] 兰风华[1] 张朵[1] 

机构地区：[1]南京军区福州总医院全军计划生育优生优育研究所,福州350025

出　　处：《解放军医学杂志》2016年第2期168-174,共7页Medical Journal of Chinese People's Liberation Army

基　　金：全军医学科技青年培育项目(13QNP042);中国博士后科学基金面上项目(12014M552703)~~

摘　　要：精原干细胞(SSC)既具有自我更新能力又能分化成精子,是雄性动物体内唯一能将遗传信息传递给子代的成体干细胞。最新研究发现,SSC在体外特殊培养条件下能够去分化形成胚胎样多潜能干细胞,进而转分化生成3个胚层来源的细胞。上述研究主要是在非灵长类动物体内进行的。本文主要针对非灵长类动物SSC的生物学特性、分离纯化、培养、鉴定、移植等进行简要的概述,并对其多潜能性及可塑性的研究进展进行讨论,旨在探讨SSC在男性不育症治疗和人类再生医学领域的应用潜能。Spermatogonial stem cells（SSCs） have the ability of self-renewal and differentiate into sperm throughout the life of male animals. They are the unique adult stem cells that transmit genetic information to subsequent generations. Recently, accumulating evidences have demonstrated that SSCs can be reprogrammed to become ES-like cells that differentiate into all cell lineages of the three germ layers. These studies were mainly focused on non-primate mammals. Therefore, this review summarized the characterization, isolation, purification, cultivation, identification and transplantation of SSCs in non-primate mammals, and discussed the unlimited pluripotency and plasticity of SSCs. We also provided valuable insights of SSCs in the treatment of male infertility and application potential of human regenerative medicine.

关 键 词：精原干细胞 多潜能性 可塑性 

分 类 号：R339.212[医药卫生—人体生理学]