以细菌主要病原体相关分子为靶标的脓毒症防治策略  

Targeting the major bacterial pathogen-associated molecular patterns as a strategy for the treatment of sepsis

作　　者：郑江[1] 郑新川[1] 

机构地区：[1]第三军医大学西南医院综合实验研究中心,重庆400038

出　　处：《第三军医大学学报》2016年第4期323-329,共7页Journal of Third Military Medical University

基　　金：国家自然科学基金面上项目(81372089);国家"重大新药创制"科技重大专项(2014ZX09102001011)~~

摘　　要：脓毒症（sepsis）是指由感染因素导致的全身性炎症反应综合征（systemic inflammatory response syndrome,SIRS）,是临床上严重感染患者常见的致命性并发症,也是感染患者死亡的主要原因。目前,全球脓毒症发病率为（50-95）/100 000,并以每年9%的速度上升,预计全球每年有1 900万病例。脓毒症的病死率长期居高不下,其中重症脓毒症病死率为25%-30％，脓毒性休克病死率则高达40％-70％，已经超过心肌梗死，成为重症监护病房非心因性死亡的首要因素。每年全球因脓毒症死亡的人数超过前列腺癌、乳腺癌和艾滋病致死人数的总和，因此被认为是严重威胁人类生命健康的重大疾病。Sepsis is a life-threatening disease for infected patients and there are few effective reme- dies for sepsis. Almost all the therapeutic strategies based on anti-inflammation or anti-coagulation have been failed since sepsis is a complicated inflammatory response that involves immune, coagulation and neuroendo- crine systems, and thus the treatments directed against only one of the systems are not able to produce benefi- cial effects. Pattern recognition theory which means the pathogen-associated molecular patterns trigger sepsis by being recognized by pattern recognition receptors, elucidates the mechanism of sepsis, therefore we present a strategy on the management of sepsis at the source by targeting the major bacterial pathogen-associated molecu- lar patterns. According to the current studies, the strategy is feasible thus providing a promising way to treat sepsis.

关 键 词：脓毒症 模式识别理论 防治策略 

分 类 号：R631[医药卫生—外科学]