斑蝥酸钠维生素B_6注射液辅助治疗肝癌37例疗效评价  

Cantharidin Sodium Vitamin B_6 Injection as Assistant Therapy for Treating Liver Cancer in 37 Cases

作　　者：方秀华[1] 徐洁[1] 

机构地区：[1]江苏省无锡市妇幼保健院,江苏无锡214002

出　　处：《中国药业》2016年第1期25-27,共3页China Pharmaceuticals

摘　　要：目的探讨斑蝥酸钠维生素B6注射液联合介入及化学治疗对肝癌的疗效,并进行成本-效果分析。方法将74例原发性肝癌患者随机分为对照组和观察组,各37例。对照组患者采用肝动脉介入灌注化学治疗药物治疗,观察组患者在对照组基础上加用斑蝥酸钠维生素B6注射液治疗,疗程均为3个月。观察患者总有效率,肿瘤血清学指标糖原类抗原(CA125)、糖类抗原(CA199)及甲胎蛋白(AFP),治疗后生活质量评分,以及治疗过程中药品相关不良反应发生率。对两组患者进行成本-效果分析以进行药物经济学评价。结果观察组患者治疗有效率为62.16%,显著高于对照组的45.95%(P<0.05)。两组患者治疗后肿瘤血清学指标水平均有明显下降(P<0.05),且观察组下降程度更明显(P<0.05)。治疗后观察组生活质量评分显著高于对照组。观察组患者疗效/费用比较对照组显著升高(P<0.05)。两组患者药品相关不良反应发生率间未见显著差异。结论斑蝥酸钠维生素B6辅助治疗肝癌疗效较满意,且安全性良好。Objective To investigate the therapeutic effect of cantharidin sodium vitamin B_6 injection combined with interventional chemotherapy in the treatment of liver cancer and to conduct the cost- effectiveness analysis. Methods 74 patients with primary liver cancer were randomly divided into control group and observation group, 37 cases in each group. The control group were treated with hepatic arterial infusion chemotherapy, the observation group were treated with cantharidin sodium vitamin B_6 injection on the basis of the control group. The treatment course was 3 months. The differences in the total effective rate of two groups,the difference of CA199,CA125 and AFP,the difference between two groups of the quality of life score of two groups were observed,and the safety of drug related adverse reactions were observed in two groups. The cost- effectiveness analysis was conducted with the drugs. Results The total effective rate of the observation group was 62. 16%, whih was significantly higher than 45. 95% of the control group（ P〈0. 05）;after treatment, the tumor indicators of the two groups were significantly decreased（ P〈0. 05）, and the observation group decreased more obviously（ P〈0. 05）; the quality of life scores in the observation group was significantly higher than that in the control group（ P〈0. 05）; the incidence rate of adverse reactions in the control group was significantly higher than that in the observation group（ P〈0. 05）. The cost- effectiveness of the control group was significantly higher than the observation group（ P〈0. 05）. There was no significant difference between the two groups in the incidence of adverse drug reactions. Conclusion The treatment of liver cancer using cantharidin sodium vitamin B_6 injection is effective and safe.

关 键 词：原发性肝癌 斑蝥酸钠维生素B6注射液 肝动脉介入 

分 类 号：R969.4[医药卫生—药理学] R979.1[医药卫生—药学]