阿卡波糖对老年冠心病合并糖耐量减低患者预后的影响及心脏保护作用  

Influence of Acarbose on Elderly Patients with Coronary Heart Disease Complicated with Impaired Glucose Tolerance and Its Heart Protective Effect

作　　者：陈佳明[1] 

机构地区：[1]上海中医药大学附属龙华医院,上海200126

出　　处：《中国药业》2016年第1期53-55,共3页China Pharmaceuticals

摘　　要：目的探讨阿卡波糖干预对老年冠状动脉粥样硬化性心脏病(简称冠心病)合并糖耐量减低(IGT)患者的临床效果及对心脏的保护作用。方法将120例合并IGT的老年冠心病患者按随机数字表法分为干预组和常规组,各60例。两组患者均给予基础调血脂等治疗措施,干预组患者加用阿卡波糖,两组患者均在医师指导下用药12个月。结果治疗后,两组患者的低密度脂蛋白胆固醇(LDL-C)、超敏C反应蛋白(hs-CRP)水平较治疗前显著降低(P<0.05),干预组的颈动脉内膜中膜厚度(IMT)、hs-CRP值均显著低于常规组(P<0.05);两组冠状动脉血管病变支数、病变程度比较,差异无统计学意义(P>0.05);干预组的不良心血管事件发生率为6.67%,显著低于常规组的18.33%(P<0.05)。结论常规治疗联合阿卡波糖治疗老年冠心病合并IGT患者可缓解微炎症状态,延缓颈动脉IMT增加,同时可减少心血管不良事件的发生率。Objective To investigate the intervention of acarbose on elderly coronary heart disease complicated with impaired glucose tolerance（ IGT） and its protective effect of the patient＇s heart. Methods 120 cases of patients with coronary heart merger of IGT were randomly divided into the intervention group and the conventional group,60 cases in each group. The two groups were given basic treatment such as lowering blood pressure,the intervention group was added with acarbose. The two groups were treated for 12 months under the guidance of doctors. Results After treatment,LDL- C,hs- CRP levels of both groups were significantly decreased than before treatment（ P〈0. 05）; IMT,hs- CRP values of the intervention group were significantly lower than the conventional group（ P〈0. 05）; coronary count vascular disease and the severity of the two groups had no significant difference（ P〈0. 05）. The rate of adverse cardiovascular events occurred in the intervention group was 6. 67%,which was significantly lower than 18. 33% of the conventional group（ P〈0. 05）.Conclusion Conventional therapy combined with acarbose in treating elderly coronary heart disease complicated with IGT can relieve micro- inflammation,anti- carotid IMT thickness,while reducing the incidence of cardiovascular events.

关 键 词：糖耐量减低 老年 冠状动脉粥样硬化性心脏病 阿卡波糖 

分 类 号：R969.4[医药卫生—药理学] R977.15[医药卫生—药学]