老年肺结核患者肺部真菌感染的临床治疗分析  

Clinical treatment of fungal pulmonary infections in elderly patients with pulmonary tuberculosis

作　　者：林日暇 冯伯荣[1] 林昌锋[1] 徐颖[1] 张玲[1] 温煦[1] 

机构地区：[1]海南省农垦三亚医院感染科,海南三亚572000

出　　处：《中华医院感染学杂志》2016年第3期580-582,共3页Chinese Journal of Nosocomiology

基　　金：海南省卫生厅科研基金资助项目(琼卫2011-9)

摘　　要：目的探讨老年肺结核患者肺部真菌感染的临床治疗方法及效果,为该病的治疗提供参考依据。方法选取医院2011年1月-2013年12月60例老年肺结核合并肺部真菌感染患者作为研究对象,将其随机分为研究组与对照组,各30例,对照组给予链霉素+乙胺丁醇治疗,研究组给予帕司烟肼+左氧氟沙星治疗,观察两组患者的临床治疗效果。结果研究组患者临床治疗总有效率、痰菌阴转率分别为93.3%、93.3%,均明显高于对照组患者的63.3%、60.0%,两组数据比较差异有统计学意义(P<0.05);治疗后两组患者的白细胞计数、血小板计数、丙氨酸转氨酶、血尿酸指标均较治疗前有不同程度的改善,且研究组改善程度明显优于对照组,两组数据比较差异有统计学意义(P<0.05)。结论临床对于老年肺结核合并肺部真菌感染患者在常规治疗基础上应用帕司烟肼与左氧氟沙星治疗方案是可行的,能显著提高复治肺结核的阴转率,值得临床应用与推广。OBJECTIVE To investigate clinical treatment and clinical effect on treating pulmonary fungal infections in elderly patients with pulmonary tuberculosis so as to provide references for treatment of the disease.METHODS Totally 60 elderly patients with tuberculosis complicated by fungal pulmonary infections during Jan.2011-Dec.2013 were selected as research subjects and were randomly divided into the study group and the control group,30 patients in each group.The control group was given streptomycin ＋ ethambutol,the study group was given pasiniazide＋levofloxacin.Clinical treatment effect was observed in both groups.RESULTS The total efficiency and the sputum conversion rate was 93.3% and 93.3%in the study group,significantly higher than 63.3% and60.0%in the control group,the difference between the two groups was significant（P〈0.05）.After treatment,the white blood cell count,platelet count,alanine aminotransferase,uric acid parameters were improved compared to before treatment for both groups and the degree of improvement in the study group was better than in the control group,the comparison of data between the two groups were significant（P〈0.05）.CONCLUSIONPasiniazide＋levofloxacin based on the conventional treatment for pulmonary fungal infections in elderly patients with tuberculosis is feasible.It can greatly improve the conversion rate of pulmonary tuberculosis,worthy of clinical application and promotion.

关 键 词：老年 肺结核 真菌感染 临床疗效 

分 类 号：R563[医药卫生—呼吸系统]