血清糖链抗原125与癌胚抗原在肺结核合并2型糖尿病患者中的临床价值  

Clinical significance of serum CA125 and CEA level in treating pulmonary tuberculosis combined with type 2 diabetes

作　　者：杨江华[1] 孙静[1] 梁曼曼[1] 王文节[1] 喻艳林[1] 

机构地区：[1]皖南医学院弋矶山医院感染性疾病科,安徽芜湖241001

出　　处：《中华医院感染学杂志》2016年第3期583-585,共3页Chinese Journal of Nosocomiology

基　　金：安徽省卫生厅基金资助项目(2012ZY60)

摘　　要：目的探讨血清糖链抗原125(CA125)与癌胚抗原(CEA)水平在继发性肺结核合并2型糖尿病患者中的诊断以及抗结核疗效价值。方法收集医院2012年1月-2013年12月163例浸润性肺结核患者临床资料,92例继发性肺结核合并2型糖尿病患者为肺结核合并糖尿病组,其中初治患者56例、复治患者36例;71例继发性肺结核患者为肺结核组,其中初治患者42例、复治患者29例;另收集21例肺细胞腺癌患者为肺癌组;36例2型糖尿病患者为糖尿病组;选择20名健康体检人员为正常对照组,采用化学发光免疫分析法检测所有受试人员血清CEA与CA125的水平,并进行比较分析;数据采用SPPS17.0统计软件进行分析。结果肺结核合并糖尿病组、肺结核组、糖尿病组及正常对照组受试人员CEA水平,均低于肺癌组患者,差异有统计学意义(P<0.01);肺结核合并糖尿病初治患者血清CA125水平为(89.92±12.03)U/ml,高于复治患者的(35.93±7.53)U/ml,高于肺结核初治患者的(46.92±14.03)U/ml与复治患者的(28.97±4.46)U/ml,且显著高于糖尿病组患者的(18.24±6.76)U/ml及正常对照组的(12.39±1.45)U/ml,低于肺癌组患者的(332.04±88.29)U/ml,差异均有统计学意义(P<0.01);经规范治疗后血清CA125水平均降至正常(P<0.001)。结论血清CA125水平可以作为评价继发性肺结核合并2型糖尿病患者病情进展、预后和临床疗效的敏感指标,联合血清CEA与CA125水平变化可用于鉴别肺结核合并2型糖尿病与肺癌患者。OBJECTIVE To evaluate the clinical value of serum cancer antigen 125（CA125）and CEA levels in patients with simultaneously secondary pulmonary tuberculosis and type 2diabetes.METHODS The clinical data of163 cases with infiltrative pulmonary tuberculosis admitted in the hospital from Jan.2012 to Dec.2013 were collected.Patients included 56 patients with simultaneously secondary pulmonary tuberculosis and type 2diabetes in initial treatment,while 36 patients who needed anti-tuberculosis re-treatment,42 patients with secondary pulmonary tuberculosis in initial treatment,while 29 patients who needed anti-tuberculosis re-treatment.Another 21 patients with lung adenocarcinoma,26 patients with type 2diabetes,and 20 healthy people were chosen as the control group.Statistical analysis was performed to determine the factors that affected the serum level of CA125.RESULTS The serum CA125 levels of patients in simultaneously secondary pulmonary tuberculosis and type 2diabetes group,anti-tuberculosis re-treatment group and patients with pulmonary tuberculosis in initial treatment group and in re-treatment group and the control group were all significantly lower than the group with lung adenocarcinoma（P〈0.01）.Serum CA125 level in initial treatment patients with lung tuberculosis and type 2diabetes were（89.92±12.03）U/ml,higher than the re-treatment group of（35.93±7.53）U/ml and lung tuberculosis initial treatment group of（46.92±14.03）U/ml and the re-treatment group of（28.97±4.46）U/ml,remarkably higher than type 2diabetes group of（18.24±6.76）U/ml and the healthy group of（12.39±1.45）U/ml.The differences were significant（P〈0.01）.But CA125 level of the lung adenocarcinoma patients was obviously high with（332.04±88.29）U/ml.The differences were significant（P〈0.01）.After standardized treatments,serum CA125 levels all dropped into the normal level（P〈0.001）.CONCLUSIONCombined serum CEA and CA125 levels can be used to identify tuberculosis and lung adenocarcinoma cancer.CA125 ca

关 键 词：肺结核 糖链抗原125 癌胚抗原 2型糖尿病 

分 类 号：R521[医药卫生—内科学]