人乳头状瘤病毒疫苗研究进展  

Research progress of HPV vaccines

作　　者：谢旭[1] 李林[1] 程璐[1] 李涵英 陈日兰[1] 

机构地区：[1]广西中医药大学附属瑞康医院妇科,广西南宁530011 [2]桂林市妇幼保健院妇科,广西桂林541001

出　　处：《中华医院感染学杂志》2016年第3期714-716,共3页Chinese Journal of Nosocomiology

基　　金：广西壮族自治区卫生厅重点基金资助项目(2011036)

摘　　要：一定型别的人乳头状瘤病毒(HPV)感染是宫颈癌发生的必备条件,预防性HPV疫苗可大量减少与此相关的宫颈病变及宫颈癌发病率和病死率,治疗性疫苗通过早期HPV基因编码蛋白的抗原表位产生免疫反应,预防性疫苗研究日渐成熟,已进入市场推广阶段,而治疗性疫苗还缺乏相应的大规模临床试验结果,该综述介绍了HPV防治性疫苗作用机制、生物学特性及其应用现状等,提出了疫苗应用及推广中出现的问题及未来研究中面临的挑战。Certain types of human papillomavirus（HPV）causing infections are prerequisites for cervical cancer,prophylactic HPV vaccines can greatly reduce the related cervical lesions and incidence and mortality of cervical cancer.It is the early protein epitopes encoded by HPV genes in therapeutic vaccines that elicit an immune response.Researches on preventive vaccines are maturing,and such vaccines have entered the marketing phase,however,therapeutic vaccines still lack of appropriate large-scale clinical trials.This paper described the mechanism of HPV vaccines for prevention and treatment and their biological characteristics and the application status and proposed problems in the application and promotion and the challenge in future research.

关 键 词：人乳头状瘤病毒 疫苗 宫颈癌 

分 类 号：R373[医药卫生—病原生物学]