E-选择素S128R基因多态性与中国人群冠心病发病相关性的Meta分析  

Correlation between E-selectin S128R polymorphism and coronary heart disease in Chinese population: a Meta-analysis

作　　者：胡龙才[1] 张卫[1] 李伟龙[1] 毛强[1] 

机构地区：[1]湖北省咸宁市通城县人民医院内二科,咸宁437400

出　　处：《中国循证心血管医学杂志》2016年第1期23-25,28,共4页Chinese Journal of Evidence-Based Cardiovascular Medicine

摘　　要：目的研究E-选择素S128R基因多态性与中国人群冠状动脉粥样硬化性心脏病（冠心病）发病相关性。方法全面检索中国知网以及Pub Med关于E-选择素S128R基因多态性与中国人群冠心病关联性的原始病例对照研究,根据文献纳入标准纳入符合标准的研究,并进行数据合并。利用E-选择素S128R基因的不同的遗传模型OR值及其95%CI作为效应指标进行分析。结果 6个原始研究共计1788例对象（其中冠心病患者938例,健康对照850例）进入最后的数据合并。杂合子比较模型和显性模型Meta分析表明E-选择素S128R基因多态性与冠心病易感性有统计学意义（R vs.S：OR=5.45,95%CI：2.69-9.69,P=0.02;RR vs.SS：OR=5.98,95%CI：1.32-27.12,P=0.02;RS vs.SS：OR=2.62,95%CI：1.94-3.53,P〈0.01;RR＋RS vs.SS：OR=2.70,95%CI：2.01-3.64,P〈0.01;RR vs.RS＋SS：OR=4.89,95%CI：1.07-22.32,P=0.04）。结论 E-选择素S128R基因多态性与中国人群冠心病易感性有关。Objective To study the correlation between E-selectin S128 R polymorphism and coronary heart disease（CHD） in Chinese population. Methods The databases of CNKI and Pub Med were retrieved for collecting the original case-control studies about the correlation between E-selectin S128 R polymorphism and CHD in Chinese population, and eligible studies were enclosed according to internalized standard and the data was merged. The values of OR and 95%CI of E-selectin S128 R different genetic models were taken as effective indexes applied in the analysis. Results There were 6 original studies（1788 cases including 938 CHD cases and 850 health controls） included in final data merging. The Meta-analysis on heterozygote comparison model and dominance model showed that the correlation between E-selectin S128 R polymorphism and CHD susceptibility had statistical significance（R vs. S： OR=5.45, 95%CI： 2.69-9.69, P=0.02; RR vs. SS： OR=5.98, 95%CI： 1.32-27.12, P=0.02; RSvs. SS： OR=2.62, 95%CI： 1.94-3.53, P0.01; RR＋RS vs. SS： OR=2.70, 95%CI： 2.01-3.64, P0.01; RR vs. RS＋SS： OR=4.89, 95%CI： 1.07-22.32, P=0.04）. Conclusion E-selectin S128 R polymorphism is correlated to CHD susceptibility in Chinese population.

关 键 词：E-选择素 S基因多态性 冠心病 META分析 

分 类 号：R541.4[医药卫生—心血管疾病]