丹红注射液联合脑心通胶囊干预高龄患者糖尿病肾病早期病变的临床研究  

Danhong Injection plus naoxintong capsule in intervention of early lesion of diabetic nephropathy in elderly patients

作　　者：魏万林[1] 张薇[2] 王晓兵[2] 田国祥[2] 武云涛[2] 夏常泉[2] 姚璐[2] 刘辉[2] 赵步长 

机构地区：[1]北京军区总医院京西医院,北京100043 [2]北京军区总医院干四科,北京100700 [3]步长脑心同治理论研究院,西安710000

出　　处：《中国循证心血管医学杂志》2016年第1期26-28,共3页Chinese Journal of Evidence-Based Cardiovascular Medicine

基　　金：2012年全军保健专项科研课题

摘　　要：目的观察丹红注射液联合脑心通胶囊干预老年早期糖尿病肾病(DN)的临床疗效。方法选取2013年2月至2015年8月北京军区总医院75岁以上的符合糖尿病肾病早期病变诊断标准的病例60例,在控制血糖的基础上将其随机分为两组,其中对照组30例使用培哚普利治疗6个月,观察组30例使用丹红注射液+脑心通胶囊联合培哚普利干预,疗程为2周,后继续使用脑心通胶囊至6个月。治疗结束后比较两组患者治疗前后24 h的尿蛋白定量、尿白蛋白排泄率变化。结果治疗后两组高龄患者24 h尿蛋白定量、尿白蛋白排泄率均有降低,与对照组相比观察组下降的更为显著(P<0.05)。观察组减少24 h蛋白尿定量的总有效率为82.75%,对照组的总有效率为55.17%,观察组降低高龄糖尿病肾病患者尿蛋白较对照组有明显优势(P<0.05)。结论使用丹红注射液联合脑心通胶囊治疗高龄老年早期糖尿病肾病的疗效优于单纯使用培哚普利。Objective To observe the clinical efficacy of Danhong Injection＋naoxintong capsule on early diabetic nephropathy（EDN） in elderly patients. Methods EDN patients aged over 75（n=60） were chosen from Feb. 2013 to Aug. 2015, and divided randomly into observation group and control group（each n=30） on the base of controlling blood sugar. The control group was treated with perindopril for 6 months, and observation group was given Danhong Injection＋naoxintong capsule and perindopril for 2 w, and then, continuous oral administration of naoxintong capsule. The changes of quantification of urine protein（UP） and urinary albumin excretion rate（UAER） were compared in 2 groups after treatment. Results After treatment, 24 h quantification of UP and UAER decreased in 2 groups, which was more significant in observation group（P〈0.05）. The total effective rate was 82.75% in observation group and 55.17% in control group（P0.05）. Conclusion The curative effect of Danhong Injection＋naoxintong capsule combining perindopril is better than that of only perindopril in elderly patients with EDN.

关 键 词：高龄 丹红注射液 脑心通胶囊 培哚普利 早期糖尿病肾病 

分 类 号：R587.1[医药卫生—内分泌]