社区获得性MRSA所致哺乳期乳腺脓肿耐药性分析  

Drug Resistance Analysis of Lactating Breast Abscess infected by Community-acquired MRSA

作　　者：李少英[1] 邹建话[2] 吴华聪[1] 吴丽娟[1] 刘小月[1] 王飞玲[1] 陈静[3] 

机构地区：[1]深圳市妇幼保健院乳腺科,深圳518133 [2]深圳市妇幼保健院检验科,深圳518133 [3]深圳市妇幼保健院超声科,深圳518133

出　　处：《北方药学》2016年第1期155-156,共2页Journal of North Pharmacy

摘　　要：目的:分析社区获得性MRSA所致哺乳期乳腺脓肿的病原菌分布和耐药状况。方法:收集153份乳腺脓肿脓汁标本进行细菌分离鉴定及药敏试验,用法国梅里埃公司生产的API鉴定系统进行细菌菌株鉴定,用K-B纸片扩散法作药敏试验。结果:金黄色葡萄球菌呈现多重耐药趋势,MRSA对青霉素的耐药率为100%,对苯唑青霉素、头孢西丁、红霉素的耐药率分别为94.3%、91.4%和80%,对左氧氟沙星和复方新诺明的敏感率均为100%。35例患者平均年龄26.8岁,一般出现在产后更早时期(P=0.0000),脓肿直径更大(P=0.0083)。结论:社区获得性MRSA是哺乳期乳腺脓肿感染的主要细菌,左氧氟沙星可作为治疗的首选药物,抗菌药物的选择应以药敏结果为指导,避免乱用和滥用抗生素。Objective：. The purpose of this study is to analyze the pathogens distribution and drug resistance of lactating breast abscess infected by community-acquired MRSA. Method： We collected 153 pus specimens of breast abscess. their drug sensitivity was tested by K-B disk diffusion method. Result： The resistance rate of MRSA to penicillin was 100%,and to oxazocilline,cefoxitin and erythromycin was up to 94.3%、91.4% and 80%. The sensitivity rate of MRSA to levofloxacin and Cotrimoxazole was 100%. The average age of the 35 cases of MRSA induced lactating breast abscess patients was 26.8 years. It generally appeared earlier during puerperal（P=0.0000）. The median size of the abscess was bigger（P=0.0083）. Conclusion： Levofloxacin can be used as the preferred drug treatment. It is of great significance for clinical diagnosis and treatment to select the antimicrobial drugs based on drug sensitivity test,avoid indiscriminate use and abuse of antibiotics.

关 键 词：MRSA 乳腺脓肿 细菌耐药性 

分 类 号：R655.8[医药卫生—外科学]