介/纳孔生物玻璃薄膜的孔结构调控及其BSA吸附  

Control on the Porestructure of Meso/Nanoporous Bioaglass Films and the Influences on BSA Adsorption

作　　者：余翠霞[1] 葛飞[1] 翁文剑[1] 程逵[1] 

机构地区：[1]浙江大学,浙江杭州310027

出　　处：《稀有金属材料与工程》2016年第S1期567-571,共5页Rare Metal Materials and Engineering

基　　金：国家自然科学基金(51272228)

摘　　要：介/纳孔生物玻璃薄膜生物活性好,并且在药物和生长因子承载等方面发挥着重要的作用。本工作采用嵌段共聚物P123模板法合成介/纳孔生物玻璃薄膜,研究了十六烷基三甲基溴化铵(CTAB)和均三甲苯(TMB)添加剂,不同溶剂组分(乙醇和水)对介/纳孔生物玻璃薄膜的孔尺寸和分布的影响。实验结果表明:添加CTAB,薄膜形成小孔径介孔和大孔交互的孔形貌;TMB加入使薄膜介孔尺寸细微增大并产生略大尺寸的纳孔;而溶剂组分中水浓度增高,胶束尺寸分布均匀性和稳定性下降,大体积纳孔的含量明显增大。其中,介孔孔径均在10nm以内,而纳孔主要变化范围为20-200nm。添加剂和溶剂作用可归结于它们对胶束形成和与硅盐离子的组装影响;不同介/纳孔的薄膜可对蛋白质吸附量进行调节。Meso/nanoporous bioglass films play an important role in such as bioactivity and drug loading. In this work, block copolymer P123 was chosen as a template, and the influences of the additives(CTAB and TMB) and solvent polarity on pore structure of meso/nanoporous bioglass films were investigated. With an increase in CTAB amount, pore size distribution becomes wide, both mesopore and nanopore tends to coexist, and the circular holes increase with bigger pore size at the end of worm-like holes. After TMB addition, the pore size of the film becomes larger. As the ratio of water/ethanol increases, the distribution of the pore size becomes wider and non-uniform, and more big holes appear. The mesopore size is within 10 nm, and the nanopore size is 20~200 nm. These are attributed to changes in miceller formation and assembly with silicate caused by the additive addition and solvent polarity. Finally, the albumin adsorption measurement shows that the adsorption amount could be adjusted by different mesopore and nanopore distribution of films.

关 键 词：胶束 嵌段共聚物 介/纳孔生物玻璃薄膜 蛋白吸附 

分 类 号：TQ171.74[化学工程—玻璃工业] TB383.2[化学工程—硅酸盐工业]