337例过敏性喉头水肿的文献分析  

Documents Analysis and Discussions of 337 Cases of Allergic Laryngeal Edema

作　　者：秦丹[1] 凌亚豪 徐伟[2] 刘宁[2] 来晓晴 杜鹏程[4] 王爱平[1,5] 靳洪涛[1,5] 

机构地区：[1]中国医学科学院药物研究所安评中心,北京100050 [2]武汉大学信息管理学院 [3]北京市东城区人力资源和社会保障局医疗保险事务管理中心 [4]德州市人民医院药剂科 [5]北京协和建昊医药技术开发有限责任公司

出　　处：《药物流行病学杂志》2016年第1期50-54,63,共6页Chinese Journal of Pharmacoepidemiology

基　　金：重大新药创制专项基金项目(编号:2013ZX09302302;2012ZX09301002-001-009)

摘　　要：目的:回顾性分析过敏性喉头水肿的主要诱因、临床表现及治疗措施,探讨其规律特点从而为其预防、发现及临床治疗提供参考。方法:检索1980-2014年间万方数据知识服务平台及中国知网数据库中有关过敏性喉头水肿的文献报道,建立"过敏性喉头水肿数据库",按照诱因对其分类描述分析,并对其临床表现和治疗措施进行词频分析。结果:查重剔除后,得到符合要求的记录337条,涉及药物、食物、保健品等10种因素,不同诱因导致的表现症状不尽相同,主要伴随症状为呼吸困难、声音嘶哑、呼吸急促、胸闷、心率加快、脉搏增快、口唇发绀、血压降低、咳嗽等;主要治疗方案多以患者取卧位吸氧及注射地塞米松、肾上腺素、异丙嗪、葡萄糖酸钙等抗过敏药物。结论:过敏性喉头水肿是一种较严重的呼吸道速发型变态反应性疾病,必须引起患者及医务工作者的重视,临床需根据不同诱因及表现症状区别治疗。Objective：To discuss the pathogens, characteristics and regularities of allergic laryngeal edema so as to provide reference for its preventions, detections and clinical treatments by retrospective analysis of the literatures. Meth- ods：The case reports of allergic laryngeal edema, published on Chinese medical periodicals from CNKI Database and Wan- fang Database during the period of 1980 to 2014, were collected to set up the ＂allergic laryngeal edema Database＂. The data were classified and analysed according to the pathogens. Results： There were 337 records involved in 10 kinds of pathogens in the database, such as drug, food, health products and so on. The mainly accompany symptoms are dyspnea, hoarseness, polypnea, chest tightness, increased heart rate, tachycardia, cyanosis lips, a lowering of blood pressure, cough, etc. The mainly clinical treatments are oxygen inhalation, injecting dexamethasone, epinephrine, promethazine, calcium gluconate and other antiallergic drugs. Conclusion： The allergic laryngeal edema was a serious allergic disease, which should be given great attention in daily life and in clinic. And the laryngeal edema patients should be treated accord- ing to different pathogens and symptoms.

关 键 词：喉头水肿 变态反应性疾病 文献分析 

分 类 号：R593.1[医药卫生—内科学]