老年慢性心力衰竭患者NT-pro BNP水平对红细胞及血小板参数的影响  

Influence of NT-pro BNP on red blood cell, platelet parameters in elderly patients with chronic heart failure

作　　者：陈梅[1] 刘翠珍[2] 周怡[2] 

机构地区：[1]泰安市中心医院老年病科,山东271000 [2]泰安市中心医院

出　　处：《社区医学杂志》2016年第1期25-27,共3页Journal Of Community Medicine

摘　　要：目的观察氨基末端脑钠肽前体(N-terminal pro brain natriuretic peptide,NT-pro BNP)对老年慢性心力衰竭(心衰)患者的诊断价值,观察其对红细胞参数和血小板参数的影响,并探讨其临床意义。方法选择2013年1月—2014年12月收治的150例老年心衰患者作为研究对象,根据患者NT-pro BNP水平分为BNP增高组55例及BNP正常组95例。记录并比较两组红细胞参数(HB、RBC、RDW、HCT)和血小板参数(MPV、PDW、P-LCR)。计量资料采用t检验,P<0.05为差异有统计学意义。结果 BNP正常组HB、RBC、RDW、HCT水平分别为(135.18±17.51)g/L、(4.52±0.57)×1012/L、(13.9±1.6)%、(40.20±7.25)%,与BNP增高组的(120.92±18.52)g/L、(3.82±0.68)×1012/L、(14.9±1.7)%、(36.63±6.26)%比较差异均有统计学意义(均P<0.05)。BNP正常组MPV、PDW水平分别为(14.7±1.2)、(16.2±1.8)fl,与BNP增高组的(18.8±2.1)、(18.0±1.5)fl比较差异均有统计学意义(均P<0.05)。结论 RDW、PDW、MPV水平可作为评价心衰患者心功能的临床指标,心衰时血小板活化,与心衰患者易发生栓塞性疾病密切相关。Objective To investigate the value of N-terminal pro brain natriuretic peptide （NT-pro BNP） level in diagnosis of chronic heart failure（CHF）,and the relationship between NT-pro BNP and red blood cell,platelet parameters in elderly patients with CHF and the clinical sigrtificance.Methods 150 elderly patients with CHF from January 2013 to December 2014 were selected,divided into high tevel BNP group（n=55） and normal level BNP group（n=95） according to the level of NT-pro BNP.The erythrocyte parameters（HB,RBC,RDW ,HCT） and platelet parameter（MPV,PDW,P-LCR） were recorded and compared.Measure- ment data was processed by t test,P〈0.05 was considered statistically significant.Results The HB,RBC,RDW,HCT level of normal level BNP group were （135.18 ± 17.51）g/L,（4.52± 0.57）×10 12/L,（13.9 ± 1.6）%,（40.20 ± 7.25）%,while in high level BNP group were （120.92 ± 18.52）g/L,（3.82 ± 0.68） × 1012/L,（14.9 ± 1.7）%,（36.63±6.26）%,the differences were statistically significant（all P〈 0.05）.The level of MPV,PDW of normal level BNP group were （14.7 ± 1.2）,（16.2 ± 1.8）fl,while in high level BNP group were （18.8 ± 2.1）,（18.0± 1.5）fl,the differences were statistically significant（all P〈0.05）.Conclusion RDW,PDW and MPV are correlation in patients with CHF.The platelets may be more reactive and contributed to thromboembolic events in patients with CHF.

关 键 词：心力衰竭 氨基末端脑钠肽前体 红细胞 血小板 

分 类 号：R541.4[医药卫生—心血管疾病]