冠心病患者红细胞分布宽度与动脉硬化的相关性  

Correlation between red blood cell distribution width and pulse wave velocity in patients with coronary artery disease

作　　者：田磊[1] 王长谦[1] 韩志华[1] 范虞琪[1] 解玉水[1] 殷兆芳[1] 曹嘉添 

机构地区：[1]上海交通大学医学院附属第九人民医院心内科,上海200011

出　　处：《心脏杂志》2016年第1期46-49,共4页Chinese Heart Journal

摘　　要：目的探讨冠心病患者红细胞分布宽度(RDW)与脉搏波传导速度(PWV)之间的相关性。方法选择冠心病患者(冠心病组)87例,健康体检者(对照组)94例。将87例冠心病患者按RDW四分位数将患者分为:最低四分位数组(A组)28例,低四分位数组(B组)21例,高四分位数组(C组)26例,最高四分位数组(D组)12例。收集临床一般资料及心血管病危险因素,测定血脂、肌酐、白细胞、血尿酸等,测量肱-踝PWV(ba PWV)。结果冠心病组RDW和ba PWV水平较正常对照组明显升高〔(13.1±0.8)%vs.(14.2±0.6)%,(1856±392)cm/s vs.(2029±649)cm/s,P<0.05〕;从A组到D组,ba PWV逐渐增高,分别为〔(1945.5±525.3),(1973.5±598.4),(2020.7±650.9),(2616.3±695.6)cm/s〕;D组与前3组之间的差异有统计学意义(P<0.05);相关分析显示,RDW与ba PWV(r=0.236,P<0.05)、年龄(r=0.220,P<0.05)呈正相关,多元线性逐步回归分析表明RDW是ba PWV的独立影响因素(B=602.52,P<0.01)。结论冠心病患者的RDW与ba PWV有相关性,RDW增高患者动脉硬化程度增加。AIM To study the correlation between red blood cell distribution width （RDW） and pulse wave velocity （PWV） in patients with coronary artery disease （CAD）. METHODS One hundred and seventy-four patients with CAD （ CAD group） and 94 healthy subjects （ control group） were enrolled. The 174 patients were divided into four groups according to quartiles of RDW ： lowest RDW quartile group （ group A, n = 28 ）, lower RDW quartile group （ group B, n = 21 ）, high RDW quartile group （ group C, n = 26） and highest RDW quartile group （group D, n = 12）. General clinical information and cardiovas- cular disease risk factors were examined and serum lipid, creatinine, white blood cells, blood uric acid and baPWV were measured. RESULTS Serum RDW and baPWV level in CAD group were obviously higher than those in control group [ （13.1 ±0. 8）% vs. （14. 2 ±0.6）%, （1856 ±392） cm/s vs. （2029 ± 649） cm/s, P 〈 0. 05 ]. From group A to group D, baPWV gradually increased [ （ 1945.5 ±525.3 ）, （ 1973.5± 598.4 ）, （ 2020. 7 ± 650. 9 ） and （ 2616. 3 ±695.6 ） em/s ] and a statistically significant difference was found between group D and the other three groups （ P 〈 0. 05 ）. Analysis showed that RDW and baPWV （ r = 0. 236, P 〈 0.05 ） and age （ r = 0. 220, P 〈 0. 05 ） were positively correlated. Multiple linear stepwise regression analysis showed that RDW was the independent risk factor for baPWV （ B = 602.52, P 〈 0. 01 ）. CONCLUSION RDW and baPWV levels increase significantly in CAD pa- tients and RDW is associated with baPWV. Patients with increased RDW have increased arteriosclerosis.

关 键 词：动脉硬化 冠状动脉疾病 红细胞分布宽度 脉搏波传导速度 

分 类 号：R541.4[医药卫生—心血管疾病]