尼可地尔治疗心脏X综合征的效果  

Effect of nicorandil on cardiac syndrome X

作　　者：吕岩[1] 贾大林[1] 

机构地区：[1]中国医科大学附属第一医院心内科,辽宁沈阳110001

出　　处：《心脏杂志》2016年第1期64-65,74,共3页Chinese Heart Journal

摘　　要：目的观察尼可地尔治疗心脏x综合征（CSX）的效果。方法选择2013年1月-12月在本科确诊的CSX的患者45例，随机分为试药组（n=23）及对照组（n=22）。两组患者均给予常规药物治疗，试药组在此基础上给予尼可地尔5mg，每日3次口服，随访3个月，观察患者胸痛改善情况，复查平板运动试验。结果对照组治疗后比治疗前劳累型心绞痛发作次数降低[（29．8±5．5）次／月郴．（20．4±4．5）次／月，P〈0．05]，试药组治疗后比治疗前降低[（31．7±3．4）次／月掷．（19．5±5．1）次／月，P〈0．05]。两组间比较试药组降低更加显著。两组的运动持续总时间、sT段最大压低幅度、运动试验中发作心绞痛人数均有改善，但试药组有更好的作用。结论尼可地尔在心脏CSX患者治疗中能够在基本治疗基础上进一步改善心绞痛症状。AIM To observe the clinical effect of nicorandil on patients with cardiac syndrome X and to analyze the treatment results. METHODS Forty-five patients diagnosed with cardiac syndrome X between January 2013 and December 2013 in our hospital were enrolled and randomly divided into nicorandil group （n = 23 ） and control group （n = 22 ）. Patients in the two groups were given routine drug treatment and, in addition, nicorandil 5 mg rid orally per day was given in nicorandil group. After a 3- month follow-up, chest pain was examined and treadmill exercise test was conducted. RESULTS Angina pectoris was reduced in both control group [ （29. 8 ±5.5 ） Times/month vs. （20. 4 ± 4. 5 ） Times/month, P 〈 0. 05 ] and nicorandil group [ （31.7± 3.4） Times/month vs. （ 19. 5 ± 5.1 ） Times/month, P 〈 0. 05 ] with better results in nicorandil group. Total duration of exercise, maximal ST segment depression, and occurrence of angina in exercise test were improved in both groups, with better results in nicorandil group. CONCLUSION： Based on the basic treatment, nicorandil can further improve the symptoms of angina pectoris in patients with cardiac syndrome X.

关 键 词：心脏X综合征 尼可地尔 ATP敏感性钾通道 心绞痛 

分 类 号：R541.4[医药卫生—心血管疾病]