青娥丸对绝经后骨质疏松症患者骨密度、骨转换标志物及骨桥蛋白的影响  

The Effect of Qing'e Pill on BMD,Bone Metabolic and OPN in Patients with Postmenopausal Osteoporosis

作　　者：余海[1,2] 徐晓娟[2] 沈霖[2] 谢晶[2] 杨艳萍[2] 帅波[2] 周丕琪[2] 

机构地区：[1]四川省成都市第五人民医院,成都611130 [2]华中科技大学同济医学院附属协和医院

出　　处：《中国中医骨伤科杂志》2016年第1期21-23,共3页Chinese Journal of Traditional Medical Traumatology & Orthopedics

基　　金：国家自然科学基金项目(81473492)

摘　　要：目的:观察古方青娥丸对绝经后骨质疏松症患者的临床疗效及骨转换标志物、骨桥蛋白的影响,探讨青娥丸改善绝经后骨质疏松症的作用机制。方法:选择绝经后骨质疏松症患者64例,随机分为青娥丸治疗组(治疗组)及模拟剂治疗组(对照组)治疗6个月。分别在治疗前后检测患者骨密度、骨转换标志物(PINP,S-CTX)、雌激素以及骨桥蛋白的浓度。结果:治疗组在治疗前后骨密度及骨形成标志物PINP、雌激素未见明显变化,骨吸收标志物S-CTX水平显著降低(P<0.05),骨桥蛋白水平亦显著降低(P<0.05);对照组骨密度持续下降,骨转化标志物及骨桥蛋白、雌激素水平无显著性差异。结论:古方青娥丸能够维持绝经后骨质疏松症患者的骨密度、抑制骨吸收,可能与抑制骨桥蛋白的表达有关。Objective： To investigate the effect of Chinese herbal Qing＇e pill on BMD,Osteopontin（OPN） and bone metabolic for treating the postmenopausal women with osteoporosis,and to explore the mechanism of improving the postmenopa- usal osteoporosis. Methods： 64 patients with postmenopausal osteoporosis were selected and randomly divided into Qing＇e Pill treatment group and placebo control group. The patients in both groups received treatment for 6 months. The BMD, bone turnover markers, estrogen levels, and OPN were detected in each patient at baseline and 6 months after treatment. Results： In Qing＇e pill treatment group, there was no significantly increased bone mineral density in either observation period, whereas S-CTX and OPN were decreased after 6 months （P〈0.05）. However, BMD levels were significantly de creased in observation periods in control group. There was no significant difference in turnover markers, estrogen levels, and OPN, compared with those at the baseline. Conclusion：Qing＇e pill is effective on maintaining BMD and inhibiting bone resorption,whitb may be related to inhibiting the expression of OPN in patients with postmenopausal osteoporosis.

关 键 词：青娥丸 绝经后骨质疏松症 骨密度 骨桥蛋白 

分 类 号：R274.39[医药卫生—中医骨伤科学]