Surface Modification of Intraocular Lenses  

作　　者：Qi Huang George Pak-Man Cheng Kin Chiu Gui-Qin Wang 

机构地区：[1]Department of Ophthalmology, Navy General Hospital of PLA, Beijing 100048, China [2]Department of Ophthalmilogy, Third Clinical Medical College of Southern Medical University, Guangzhou, Guangdong 510515, China [3]Department of Ophthalmology, Hong Kong Laser Eye Center, Hong Kong 999077, China [4]Department of Ophthalmology, Laboratory of Retina Brain Research, l:he Univeisity of Hong Kong, Hong Kong 999077, China [5]State Key Laboratory of Brain and Cognitive Sciences, The University of Hong Kong, Hong Kong 999077, China [6]Research Centre of Heart, Brain, Hormone and Healthy Aging, The University of Hong Kong, Hong Kong 999077, China

出　　处：《Chinese Medical Journal》2016年第2期206-214,共9页中华医学杂志（英文版）

摘　　要：Objective： This paper aimed to review the current literature on the surface modification ofintraocular lenses （IOLs）. Data Sources： All articles about surface modification of IOLs published up to 2015 were identified through a literature search on both PubMed and ScienceDirect. Study Selection： The articles on the surface modification of 1OLs were included, but those on design modification and surface coating were excluded. Results： Technology of surface modification included plasma, ion beam, layer-by-layer self-assembly, ultraviolet radiation, and ozone. The main molecules introduced into IOLs surface were poly （ethylene glycol）, polyhedral oligomeric silsesquioxane, 2-methacryloyloxyethyl phosphorylcholine, TiO2, heparin, F-heparin, titanium, titanium nitride, vinyl pyrrolidone, and inhibitors of cytokines. The surface modification either resulted in a more hydrophobic lens, a more hydrophilic lens, or a lens with a hydrophilic anterior and hydrophobic posterior surface. Advances in research regarding surface modification of ｜OLs had led to a better biocompatibility in both in vitro and animal experiments. Conclusion： The surface modification is an efficient, convenient, economic and promising method to improve the biocompatibility of IOLs.Objective： This paper aimed to review the current literature on the surface modification ofintraocular lenses （IOLs）. Data Sources： All articles about surface modification of IOLs published up to 2015 were identified through a literature search on both PubMed and ScienceDirect. Study Selection： The articles on the surface modification of 1OLs were included, but those on design modification and surface coating were excluded. Results： Technology of surface modification included plasma, ion beam, layer-by-layer self-assembly, ultraviolet radiation, and ozone. The main molecules introduced into IOLs surface were poly （ethylene glycol）, polyhedral oligomeric silsesquioxane, 2-methacryloyloxyethyl phosphorylcholine, TiO2, heparin, F-heparin, titanium, titanium nitride, vinyl pyrrolidone, and inhibitors of cytokines. The surface modification either resulted in a more hydrophobic lens, a more hydrophilic lens, or a lens with a hydrophilic anterior and hydrophobic posterior surface. Advances in research regarding surface modification of ｜OLs had led to a better biocompatibility in both in vitro and animal experiments. Conclusion： The surface modification is an efficient, convenient, economic and promising method to improve the biocompatibility of IOLs.

关 键 词：BIOCOMPATIBILITY Capsule Biocompatibility CATARACT Intraocular Lenses Surface Modification Uveal Biocompatibility 

分 类 号：O7[理学—晶体学] TG174.444[金属学及工艺—金属表面处理]