胃饥饿素:生物学特征及对动物采食量的调控  

Ghrelin: Biological Characteristics and Modulation of Feed Intake

作　　者：李振远[1] 李方方[1] 张勇[1] 朱宇旌[1] 

机构地区：[1]沈阳农业大学畜牧兽医学院,沈阳110866

出　　处：《动物营养学报》2016年第1期35-42,共8页CHINESE JOURNAL OF ANIMAL NUTRITION

基　　金：国家自然科学基金(31440082;31101253)

摘　　要：胃饥饿素又称作生长激素释放肽,最初是在大鼠的胃内被发现的,它是生长激素促分泌素受体1A(GHSR-1A)的一种内源性配体。在下丘脑弓形核(ARC)及室旁核(PVN)高度表达GHSR-1A的区域,胃饥饿素结合GHSR-1A后,产生一系列生物学效应。本文综述了胃饥饿素的生物学特征及功能、对动物采食量调控的机制、影响胃饥饿素基因表达调控的因素和反馈抑制以及前景展望。Ghrelin,also known as growth hormone releasing peptide,is originally discovered in the stomach of rats,and it is an endogenous ligand of growth hormone secretagogue receptor-1A（ GHSR-1A）. In the hypothalamic arcuate nucleus（ ARC） and paraventricular nucleus（ PVN）,G HSR-1A is highly expressed. In these areas,ghrelin has a series of biological effects after combining GHSR-1A. This paper reviewed biological characteristics and functions,the regulation mechanism on animal feed intake,factors influencing gene expression and modulation,feedback inhibition of ghrelin,and gave outlooks for researches into ghrelin in the future.

关 键 词：胃饥饿素 生长激素促分泌素受体1A 采食量 星形胶质细胞 刺鼠相关蛋白 

分 类 号：S852.2[农业科学—基础兽医学]