OSAHS导致勃起功能障碍与血清NO和NOS相关性的临床观察  

Clinical observations of correlation of NO and NOS with ED caused by OSAHS

作　　者：胡海翔[1] 沈传运 徐少强[1] 高雅静[3] 丁浩浩[4] 张启龙[4] 谢亚兰[2] 孙哲[2] 韦仕福 

机构地区：[1]中国人民解放军空军总医院中西医结合男科,北京100142 [2]大连医科大学,辽宁大连116000 [3]北京中医药大学,北京100029 [4]贵阳中医学院,贵阳550002

出　　处：《中国性科学》2016年第1期5-7,共3页Chinese Journal of Human Sexuality

基　　金：首都卫生发展科研专项项目(首发2011-5041-03)

摘　　要：目的:临床探讨阻塞性睡眠呼吸暂停低通气综合征(OSAHS)导致阴茎勃起功能障碍(ED)与外周血一氧化氮(NO)和一氧化氮合酶(NOS)水平的相关性。方法:经多导睡眠监测仪(PSG)及阴茎夜间勃起功能测定(NPT),诊断OSAHS合并ED患者60名作为ED组,同时随机选择30名健康志愿者设立为健康组,分析ED组和健康组血清NO和NOS水平,及轻、中、重ED组血清NO、NOS水平、阴茎血容积变化率及IIEF-5总分差异,并将轻、中、重ED组阴茎血容积变化率及IIEF-5总分分别与各自血清NO和NOS水平进行相关性分析。结果:ED组的外周血NO和NOS水平均低于无ED组和健康组,差异具有统计学意义(P<0.05)。阴茎血容积变化率与NO(r=0.356,P<0.05)、NOS(r=0.398,P<0.05)均为正相关;IIEF-5总分与NO(r=0.402,P<0.05)、NOS(r=0.423,P<0.05)均为正相关。结论:OSAHS导致的ED患者与患者外周血NO和NOS水平变化情况的具有相关性,且呈正相关,说明外周血NO和NOS水平的降低是OSAHS导致ED的内在病理基础。Objectives：To investigate the clinical correlation of NO and NOS with ED caused by OSAHS.Methods：60 ED patients combined with OSAHS diagnosed by polysomnography meter（ PSG） and nocturnal penile erectile function test（ NPT） were selected as ED group and 30 healthy volunteers were randomly selected as healthy group to analyze serum NO and NOS levels of the two group as well as the serum NO,NOS levels,penile blood volume rate of change and IIEF-5 score differences of mild,moderate and severe ED groups.correlation analysis was done between penile blood volume and rate of change IIEF-5 scores the mild,moderate and severe ED groups and the serum NO and NOS levels.Results：Peripheral blood NO and NOS levels of ED group were lower than those of non-ED group and healthy group,the difference was statistically significant（ P 0 05）.Penile blood volume change rate and NO（ r = 0.356,P〈 0 05.）,NOS（ r = 0.398,P〈 0 05.） were positive correlation;IIEF-5scores and NO（ r = 0.402,P〈 0.05）,NOS（ r = 0.423,P〈 0.05） were positively correlated.Conclusions：ED caused by OSAHS and peripheral blood levels of NO and NOS changes are positively correlated,indicating that reduction of peripheral NO and NOS levels are internal pathological basis of ED caused by OSAHS.

关 键 词：阻塞性睡眠呼吸暂停低通气综合征 阴茎勃起功能障碍 一氧化氮 一氧化氮合酶 相关 

分 类 号：R698[医药卫生—泌尿科学]