丁苯酞注射液对急性脑梗死疗效及超敏C反应蛋白的影响  

Efficacy of Butylphthalide Injection in Treating Acute Cerebral Infarction and Its Influence on High Sensitivity Reactive C Protein

作　　者：曹姗[1] 董辉[2] 

机构地区：[1]河北省保定市第一中心医院,河北保定071000 [2]华北石油管理局总医院,河北沧州062550

出　　处：《中国药业》2016年第2期30-32,共3页China Pharmaceuticals

基　　金：河北省保定市科学研究与发展计划项目;项目编号:14ZF057

摘　　要：目的观察丁苯酞注射液治疗急性脑梗死的临床疗效及对超敏C反应蛋白(hs-CRP)的影响。方法选取2012年10月至2014年11月医院收治的急性脑梗死患者90例,按治疗方法不同分为对照组和试验组,各45例。对照组患者给予胞磷胆碱治疗,试验组患者给予丁苯酞注射液治疗。结果试验组患者总有效率为93.33%,明显高于对照组的73.33%(P<0.05);治疗后,试验组治疗14 d后的神经功能缺损评分(NIHSS)评分为(6.82±1.22)分,明显低于本组治疗前的(13.32±3.29)分及对照组治疗后14 d的(9.97±1.70)分(P<0.05);试验组hs-CRP水平为(2.72±2.92)mg/L,明显低于本组治疗前的(6.73±3.97)mg/L及对照组治疗后的(4.61±3.51)mg/L(P<0.05)。结论丁苯酞注射液治疗急性脑梗死疗效明显,可有效改善临床症状,抑制炎性反应,促进神经细胞功能的恢复,值得临床推广。Objective To investigate the clinical efficacy of Butylphthalide Injection in treating acute cerebral infarction patients and its influence on high sensitive C reactive protein（hs — CRP）.Methods 90 cases of acute cerebral infarction patients from October 2012 to November 2014 were divided into two groups according to treatment methods,45 cases in the control group were given citicoline treatment,and 45 cases in the experimental group were given Butylphthalide Injection.Results The total effective rate of the experimental group was 93.33%,which was significantly higher than 73.33%of the control group（P〈 0.05）;after treatment,the NIHSS score after 14 d of treatment of the experiment group was（6.82 ± 1.22） points,which was significantly lower than（13.32 ± 3.29）points before treatment and the control group＇s（9.97 ± 1.70） points after 14 d treatment;the hs- CRP level of the experiment group was（2.72±2.92） mg/L,which was significantly lower than（6.73 ± 3.97） mg/L before treatment and the（4.61±3.51） mg/L of the control group after treatment（P〈 0.05）.C onclusion Butylphthalide Injection in treating acute cerebral infarction has significant efficacy,can effectively improve the clinical symptoms of the patients,the inflammatory reaction is suppressed,promote nerve cell function recovery of patients,which is worthy of clinical promotion.

关 键 词：急性脑梗死 丁苯酞注射液 神经功能缺损评分 超敏C反应蛋白 

分 类 号：R969.4[医药卫生—药理学] R971[医药卫生—药学]