白柏颗粒质量标准初步研究  

Quality Standard of Baibai Granules

作　　者：王玉鹏[1] 黄顺旺[2,3] 陈师农 孙备 李玲芝[3] 宋少江[3] 

机构地区：[1]武警安徽省总队医院,安徽合肥230041 [2]安徽省食品药品检验研究院,安徽合肥230022 [3]沈阳药科大学中药学院,辽宁沈阳110016

出　　处：《中国药业》2016年第2期72-74,共3页China Pharmaceuticals

摘　　要：目的建立白柏颗粒质量标准。方法采用薄层色谱法对处方中的白术、党参、茯苓、黄芪进行定性鉴别;采用高效液相色谱法对样品中的甘草酸进行含量测定。结果薄层鉴别的分离度好,专属性强,阴性对照无干扰;含量测定甘草酸质量浓度（以甘草酸单铵盐计）在6~60μg/mL范围内与峰面积线性关系良好（r=0.999 9）,平均回收率为98.89%（n=6）,RSD为0.66%。结论所建立的方法准确、可靠、专属性强,可用于该制剂的质量控制。Objective To establish the quality standards of Baibai Granules.M ethods The atractylodes macrocephala,codonopsis pilosula,poria cocos,astragalus membranaceus were indentified by TLC,and the content of glycyrrhizic acid was determined by HPLC.Results The characteristic identification by TLC was distinct and highly specific.Glycyrrhizic acid showed a good liner relationship at the range of 6-60μg/mL（r= 0.999 9）,and the average recovery rate was 98.89%with RSD of 0.66%（n = 6）.Conclusion The method is reliable,accurate and specific,which can be used for the quality control of the preparation.

关 键 词：白柏颗粒 甘草酸 薄层色谱法 高效液相色谱法 

分 类 号：R284.1[医药卫生—中药学] R286.0[医药卫生—中医学]