原发性高血压患者血浆SCUBE1的水平变化及临床意义  

Change of Plasma SCUBE1 Level and Its Clinical Significance in the Patients with Essential Hypertension

作　　者：王美方[1] 王忠[2] 王丽[2] 陈少泽[2] 段军仓[2] 赵若飞[1] 郑丽华[1] 

机构地区：[1]石河子大学医学院,新疆石河子市832002 [2]石河子大学医学院第一附属医院心内二科,新疆石河子市832008

出　　处：《中国动脉硬化杂志》2016年第1期63-66,共4页Chinese Journal of Arteriosclerosis

基　　金：新疆生产建设兵团医药专项课题(2012AB014)

摘　　要：目的探讨原发性高血压(EH)患者血浆中新型血小板活化蛋白SCUBE1的水平变化及其与血压的相关性。方法选择2013年12月在石河子大学医学院第一附属医院体检中心筛选的EH患者77例为EH组,选择同期体检的正常健康者75例为对照组。用酶联免疫吸附法检测血浆SCUBE1水平。测定两组血压、腰臀比、体质指数、空腹血糖、总胆固醇、甘油三酯、高密度脂蛋白胆固醇、低密度脂蛋白胆固醇、尿素氮、肌酐、尿酸等指标。分析SCUBE1与各指标的相关性。结果 EH组血浆SCUBE1水平显著高于对照组(76.95±13.87μg/L比58.34±13.06μg/L,P<0.001)。EH组收缩压、舒张压、腰臀比、体质指数、空腹血糖、甘油三酯显著高于对照组(P<0.001或P<0.05)。相关分析和线性回归分析显示,SCUBE1与收缩压、舒张压呈显著正相关(P<0.05)。结论EH患者血浆SCUBE1水平升高。SCUBE1与收缩压、舒张压呈显著正相关。Ahn To explore the change of plasma level of the new type platelet activating protein SCUBE1 and its correlation with blood pressure in patients with essential hypertension （EH）. Methods 77 EH patients screened in Physical Examination Center of the First Affiliated Hospital of Shihezi University were selected for the EH group in December 2013. 75 normal healthy persons during the same period were as the control group. Plasma level of SCUBE1 was detected by enzyme-linked immunosorbent assay. Blood pressure, waist hip ratio （WHR）, body mass index （ BMI）, fasting blood glucose （FBG）, total cholesterol, triglyceride （TG） , high density Lipoprotein cholesterol, low density lipoprotein cholesterol, urea nitrogen, creatinine and uric acid were measured in the two groups. Correlation between SCUBE1 and the indexes was analyzed. Results The plasma level of SCUBE1 in EH group was significantly higher than that in control group （76. 95 ± 13.87 p,g/L vs 58. 34 ± 13.06 μg/L, P 〈 0. 001 ）. Systolic blood pressure （ SBP）, diastolic blood pressure （DBP）, WHR, BMI, FBG and TG in EH group were significantly higher than those in control group （P 〈 0. 001 or P 〈 0. 05）. Correlation analysis and linear regression analysis showed that SCUBE1 was positively correlated with SBP and DBP （P 〈 0. 05）. Conclusions The plasma level of SCUBE1 is increased in EH patients. SCUBE1 is positively correlated with SBP and DBP.

关 键 词：原发性高血压 SCUBE1 收缩压 舒张压 相关性 

分 类 号：R544[医药卫生—心血管疾病]