不同剂量阿托伐他汀对稳定型心绞痛患者循环血中内皮祖细胞的影响  

Effects of Dose-dependent Atorvastatin on the Numbers of Endothelial Progenitor Cells in Patients with Stable Coronary Heart Disease

作　　者：苗莉[1] 罗先润[1] 高爱社[2] 魏娜[1] 张辉[1] 娄云霄[1] 刘安丰[1] 

机构地区：[1]武警河南总队医院心内科,河南省郑州市450052 [2]河南中医学院病生教研室,河南省郑州市450008

出　　处：《中国动脉硬化杂志》2016年第1期81-84,共4页Chinese Journal of Arteriosclerosis

摘　　要：目的观察不同剂量的阿托伐他汀对稳定型心绞痛患者循环血中内皮祖细胞数量的影响。方法选取稳定型心绞痛患者84例,分别给予不同剂量的阿托伐他汀10 mg/d、20 mg/d、40 mg/d或80 mg/d治疗共4周。用免疫荧光法检测各组患者用药前后循环血中内皮祖细胞的数量。结果不同剂量的阿托伐他汀应用后内皮祖细胞的数量均较用药前显著性增加(P<0.05),并且内皮祖细胞的数量在40 mg/d组最高,与10 mg/d及20 mg/d组相比有显著性差异(P<0.05),80 mg/d组较40 mg/d组略有下降,但无统计学差异(P>0.05)。结论阿托伐他汀具有剂量依赖性地促进冠心病患者循环血中内皮祖细胞数量增加的作用。Aim To investigate the effects of dose-dependent atorvastatin on the numbers of endothelial progenitor cells in patients with stable coronary heart disease. Methods 84 patients with stable coronary heart disease were randomly divided into treatment groups with atorvastatin （10, 20, 40, 80 mg/d） for 4 weeks. Circulating endothelial progenitor cells numbers were determined by immunfluorescence analysis. Results The numbers of endothelial progenitor cells were all increased by different dose atorvastatin （P 〈 0. 05）, maximum at 40 mg/d and had statistical difference compared with 10 mg/d and 20 mg/d （ P 〈 0.05 ）. Endothelial progenitor cells numbers at the dose of 80 mg/d were slightly reduced compared with 40 mg/d, but there was no statistical difference （P 〉 0.05 ）. Conclusion Atorvastatin dose-dependently improve the endothelial progenitor cells numbers in the patients with stable coronary heart disease.

关 键 词：内皮祖细胞 稳定型心绞痛 阿托伐他汀 

分 类 号：R5[医药卫生—内科学]