肝硬化低蛋白血症患者股骨干骨折感染的研究  

Prevalence of infections in cirrhosis hypoproteinemia patients complicated with femoral shaft fracture

作　　者：贾蓓[1] 刘建宁[2] 柳立平[1] 马文波[1] 张岁[1] 解从君[1] 王海舫[1] 

机构地区：[1]河北医科大学第一医院感染性疾病科,河北石家庄050031 [2]河北医科大学第三医院骨科,河北石家庄050051

出　　处：《中华医院感染学杂志》2016年第4期873-874,879,共3页Chinese Journal of Nosocomiology

基　　金：河北省医学科学研究重点基金资助项目;河北省医学科学研究重点基金资助项目(20150299)

摘　　要：目的研究肝硬化低蛋白血症患者股骨干骨折后发生感染及预后,评估肝硬化低蛋白血症对股骨干骨折预后的影响。方法选择2012年2月-2015年5月骨科收治的股骨干骨折合并肝硬化低蛋白血症患者24例为观察组,另选择股骨干骨折无肝硬化低蛋白血症患者56例为对照组,均采用股骨静态交锁髓内钉固定治疗,观察两组患者术后感染率、临床疗效及随访结果;所有数据均采用SPSS 19.0进行统计分析。结果对照组患者发生切口感染率8.93%、复发感染率1.79%,观察组患者切口感染率87.50%、复发感染率50.00%,两组比较,差异有统计学意义(P<0.05);观察组患者术后出血量、术后引流量均明显多于对照组,观察组患者住院时间明显长于对照组,两组之间差异均有统计学意义(P<0.05);观察组临床治疗总有效率为58.33%、对照组为94.64%,两组比较差异有统计学意义(P<0.05)。结论肝硬化低蛋白血症显著增加股骨干骨折患者术后感染发生率和病死率,降低临床疗效。OBJECTIVE To investigate the prevlance of infections in the cirrhosis hypoproteinemia patients complicated with femoral shaft fracture,analyze the prognosis,and evaluate the impact of cirrhosis hypoproteinemia on prognosis of femoral shaft fracture.METHODS Totally 24 femoral shaft fracture patients complicated with cirrhosis hypoproteinemia who were treated in the orthopedics department from Feb 2012 to May 2015 were assigned as the observation group,and 56 femoral shaft fracture patients without cirrhosis hypoproteinemia were chosen as the control group.All of the patients were treated with anti-rotation proximal femoral nail fixation,the incidence of postoperative infections,clinical efficacy,and results of the follow-up were observed and compared between the two groups of patients,and the statistical analysis of data was performed with the use of SPSS 19.0software.RESULTS The incidence of incision infections was 8.93%in the control group,87.50%in the observation group;the rate of recurrence of infections was 1.79%in the control group,50.00%in the observation group,and there was significant difference between the two groups（P〈0.05）.The postoperative bleeding volume and drainage volume of the observation group were significantly more than those of the control group;the length of hosptial stay of the observation group was significantly longer than that of the control group（P〈0.05）.The total effective rate of clinical treatment of the observation group was 58.33%,the control group 94.64%,and there was significant difference between the two groups（P〈0.05）.CONCLUSIONThe cirrhosis hypoproteinemia may result in the significant increase of incidence of postoperative infections and mortality rate of the femoral shaft fracture patients and reduce the clinical efficacy.

关 键 词：肝硬化 低蛋白血症 股骨干骨折 感染 并发症 

分 类 号：R681.8[医药卫生—骨科学]