患者脑卒中前与后感染模型研究进展  

Research progress of pre-and post-stroke infection models for stroke patients

作　　者：孟祥博[1] 杨加亮[1] 陈天笑[1] 石焱[2] 陈丽娜[1] 

机构地区：[1]杭州市第一人民医院康复医学科,浙江杭州310006 [2]杭州市第一人民医院针灸科,浙江杭州310006

出　　处：《中华医院感染学杂志》2016年第4期958-960,共3页Chinese Journal of Nosocomiology

基　　金：浙江省中医药科学研究基金资助项目(2015ZA132);杭州市卫生局基金资助项目(2013A01)

摘　　要：感染性疾病是脑卒中后最常见的并发症;通过回顾近年来关于卒中与感染关系的文献,分析卒中和感染之间的相互影响;多项研究指出继发性免疫抑制状态是患者卒中后感染高发的一个关键因素,而建立局灶性脑缺血小鼠模型可能有助于证明神经免疫机制在脑卒中后感染进展中的作用;另外,近年研究表明,感染也是脑卒中的危险因素之一;因此,选用合适的卒中相关感染模型,阐明其相互关系的基本机制和研发新的治疗策略,可改善患者的疾病临床转归。Infectious diseases are the most common complications after stroke.This paper reviewed the literature on the relationship between strokes and infections in recent years,and analyzed the interaction between strokes and infections.Many researches point out that the secondary immunosuppressive state is a key factor for high incidence of post-stroke infections,and the establishment of the mouse model of focal cerebral ischemia may help to prove the role of neuroimmunological mechanisms in the development of post-stroke infections.In addition,the researches in the recent years reveal that infection is one of the risk factors for stroke.Therefore,using suitable models of stroke-associated infections,which is to clarify the basic mechanisms of the mutual relationship and develop new treatment strategies,may improve the clinical outcome of the patients.

关 键 词：脑卒中 感染 免疫抑制 

分 类 号：R651.1[医药卫生—外科学]