稳定型心绞痛患者血浆炎性因子水平及意义  

Value of levels of plasma inflammatory factors in patients with stable angina

作　　者：王静怡[1] 王志武[1] 刘素丽[1] 金芳[1] 宋月霞[1] 胡建[1] 

机构地区：[1]河北省唐山市人民医院功能检查科,063000

出　　处：《中国医药》2016年第2期162-164,共3页China Medicine

摘　　要：目的检测稳定型心绞痛（SAP）患者血浆炎性因子水平，探讨其临床意义。方法选取2013年6月至2015年6月于河北省唐山市人民医院进行治疗的SAP患者203例，对所有患者随访至2015年11月，以发生急性冠状动脉综合征（ACS）为终点事件，最终4例失访。根据随访结果将199例患者分为ACS组（41例）及无ACS组（158例）。比较2组患者血浆肿瘤坏死因子α（TNF-α）、白细胞介素1β（IL-1β）及高敏C反应蛋白（hs．CRP）水平，并分析3种炎性因子间的相关性。结果ACS组TNF-α、IL-1β、hs—CRP水平均明显高于无ACS组[（20±13）ng／L比（17±9）ng／L、（17±11）ng／L比（13±8）ng／L、（9±5）mg／L比（5±4）mg／L]，差异均有统计学意义（均P〈0．05）。相关性分析显示，TNF-α、IL-1β、hs—CRP两两之间均有明显相关性（均P〈0．05）。结论血浆炎性因子高水平可能在SAP进展至ACS过程中发挥重要作用。Objective To investigate the levels of plasma inflammatory factors in patients with stable angina and explore its clinical significance. Methods Totally 203 patients with stable angina from June 2013 to June 2015 were enrolled and followed up to November 2015, acute coronary syndrome （ACS） was defined as the end point event. According to the follow-up result, 199 patients （4 patients were lost in follow-up） were divided into ACS group （41 cases） and non-ACS group （158 cases）. The levels of tumor necrosis factor α （TNF-α）, intorleukin-1 β （ IL-1 β） and high-sensitivity C-reactive protein （hs-CRP） in plasma were compared, the correlations of them were analyzed. Result The levels of TNF-α, IL-1β and hs-CRP in ACS group were significantly higher than those in non-ACS group [ （20 ± 13） ng/L vs （ 17 ±9） ng/L, （ 17± 11 ） ng/L vs （ 13 ± 8） ng/L, （9±5） mg/L vs （5 ±4） mg/L] （P 〈0.05） ; there was significant positive correlation between one and any of the other two inflammatory factors （ P 〈 0. 05 ）. Conclusion High levels of inflammatory factors may play an important role in progress of stable angina to ACS.

关 键 词：稳定型心绞痛 急性冠状动脉综合征 炎性因子 

分 类 号：R541[医药卫生—心血管疾病]