机构地区:[1]首都医科大学宣武医院心脏科,北京100053
出 处:《中国医药》2016年第2期176-180,共5页China Medicine
摘 要:目的比较血脂异常且无糖尿病和商血压患者与健康对照者心-踝血管指数(CAVI)的差异,为临床干预提供参考。方法选取2012年9月至2014年5月于首都医科大学宣武医院治疗的血脂异常且无糖尿病和高血压患者169例作为观察组。其中,高胆固醇血症患者(FH亚组)103例,混合型高脂血症患者(CH亚组)66例。选取同期入院体检的264名健康志愿者纳入对照组。收集并比较观察组与对照组性别、年龄、体重指数、吸烟情况、总胆固醇、高密度脂蛋白胆固醇(HDL—c)、低密度脂蛋白胆固醇(LDL—c)、三酰甘油、载脂蛋白A、载脂蛋白B、收缩压、舒张压和CAVI。结果观察组、FH亚组及CH亚组的总胆固醇、LDL.C、三酰甘油、载脂蛋白B、舒张压与对照组比较[6.1(4.3,10.4)、6.4(4.3,9.6)、6.0(4.7,10.4)mmol/L比4.9(3.2,6.5)mmol/L,4.2(2.5,6.4)、4.3(2.5,6.1)、4.1(2.6,6.4)mmol/L比2.7(1.4。2.8)mmol/L,1.4(0.5,7.1)、1.2(0.5,7.0)、1.6(0.5,7.1)mmol/L比0.8(0.3,2.4)retool/L,1.1(0.6,1.8)、1.3(0.7,1.8)、1.1(0.6,1.7)g/L比0.8(0.8,1.9)g/L,80(70,101)、80(71,94)、80(73,101)mmHg(1mmHg:0.133kPa)比87(71,103)mmHg],差异均有统计学意义(均P〈0.05);观察组、CH亚组的HDL—C和CAVI与对照组比较[1.6(1.0,2.5)、1.8(1.5,2.5)mmol/L比1.4(1.0,2.2)mmol/L,7.9(5.6,10.1)、8.4(6.1,10.1)比7.2(5.4,10.3)],差异有统计学意义(P〈0.05);CH亚组载脂蛋白A低于对照组[1.5(1.3,3.2)g/L比1.7(1.2,3.3)g/L],差异有统计学意义(P〈0.05);FH亚组与CH亚组患者HDL—C、LDL—c和三酰甘油比较[1.4(1.0,2.2)mmol/L比1.8(1.5,2.Objective To compare the cardio-ankle vascular index (CAVI) between health persons and dyslipidemia patients without diabetes and hypertension. Methods One hundred and sixty-nine dyslipidemia patients ( observation group) without diabetes and hypertension from September 2012 to May 2014 were selected and were divided into hypercholesterolemia subgroup (FH subgroup, 103 cases) and hyperlipidemia subgroup (CH subgroup, 66 eases). In addition, 264 healthy volunteers were enrolled (control group). The gender, age, body mass index ( BMI), smoking status, total cholesterol ( TC ) , high density lipoprotein-cholesterol ( HDL-C), low density lipoprotein-cholesterol ( LDL-C), triglyceride (TG) , apoli poprotein A( Apo A), Apo B, blood pressure and CAVI were compared among groups. Results The levels of TC, LDL-C, TG, Apo B and diastolic blood pressure in observation group, FH subgroup and CH subgroup were all significantly different with those in control group [6.1 (4.3, 10.4), 6.4 (4.3, 9.6), 6.0 (4.7, 10.4) mmol/L vs 4.9 (3.2, 6.5) mmol/L, 4.2 (2.5, 6.4), 4.3 (2.5, 6.1), 4.1 (2.6, 6.4) mmol/L vs 2.7 (1.4, 2.8) mmol/L, 1.4 (0.5, 7.1), 1.2 (0.5, 7.0), 1.6 (0.5, 7.1) mmoL/L vs 0.8 (0.3, 2.4) mmol/L, 1.1 (0.6, 1.8), 1.3 (0.7, 1.8), 1.1 (0.6, 1.7) g/L vs 0.8 (0.8, 1.9) g/L, 80 (70, 101), 80 (71, 94), 80 (73, 101) mmHg vs 87 (71, 103) mmHg] (P 〈0.05) ; the HDL-C and CAVI in observation group and CH subgroup were significantly different with those in control group I 1.6 ( 1.0, 2.5), 1.8 ( i. 5, 2.5 ) mmol/L vs 1.4 (1.0, 2.2) mmol/L, 7.9 (5.6, 10.1), 8.4 (6.1, 10.1) vs7.2 (5.4, 10.3)] (P〈0.05); the Apo A in CH subgroup was significantly lower than that in control group [ 1.5 ( 1.3, 3.2) g/L vs 1.7 ( 1.2, 3.3) g/L] (P 〈0.05); the levels of HDL-C, LDL-C and TG in FH subgroup and CH subgroup were significantly different [ 1.4 ( 1. 0, 2.2) mmol/L vs 1.8 (1
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