中药分阶段介入对提高体外受精-胚胎移植孕育率的临床随机对照研究  

Effect of phased treatment with Chinese medical herbs in improving pregnant rate of vitro fertilizationembryo transfer

作　　者：姬晓兰[1] 李东[1] 郭佳[1] 刘承[1] 

机构地区：[1]北京大学第三医院中医科,100191

出　　处：《中国医药》2016年第2期258-260,共3页China Medicine

基　　金：首都医学发展基金（SF-2009-Ⅲ-33）

摘　　要：目的研究中药分阶段介入对提高体外受精-胚胎移植（IVF—ET）技术孕育率的影响。方法选取2011年6月至2012年6月在北京大学第三医院生殖医学中心就诊，符合女性输卵管因素、男性因素不孕分类诊断，适合接受IVF／卵泡浆内单精子注射（ICSI）-ET的患者368例。将所有患者随机分为观察组和对照组，各184例。所有患者均根据个体情况选择适宜的常规COH方案，观察组于促排卵周期月经第2—3天至取卵前服用补肾养血活血中药，在胚胎移植后着床阶段服用温肾安胎中药，观察胚胎移植后14d的血β-人绒毛膜促性腺激素水平和移植后30d超声检查结果，计算生化妊娠率、临床妊娠率、胚胎种植率、早期流产率，并与对照组进行比较。结果对照组和观察组最终完成研究分别为169例和160例。观察组生化妊娠率和临床妊娠率均高于对照组，差异有统计学意义[52．5％（84／160）比39．6％（67／169）、44．4％（71／160）比33．7（57／169），P〈0．05]；胚胎种植率、早期流产率2组差异无统计学意义（P〉0．05）。结论补肾养血活血中药与温。肾安胎中药分阶段介入IVF—ET，能够促进胚胎着床，提高临床妊娠率。Objective To study the effect of phased treatment with Chinese medical herbs in improving pregnant rate of vitro fertilization-embryo transfer （IVF-ET）. Methods Totally 368 infertility patients according to the female fallopian tube or male infertility criteria who were suitable for IVF/intracytoplasmie sperm injection （ICSI）-ET treatment from June 2011 to June 2012 were randomly divided into observation group and control group （184 cases in each group）. All the patients underwent appropriate controlled ovarian hyperstimulation （COH）; observation group was given Chinese medical herbs of reinforcing kidney, nourishing and activating blood （RKNAB） from the menstrual period 2-3 day of COH to the day of oocyte retrieval operation, then was given Chinese medical herbs of warming kidney and calming fetus （WKCF） on embryo implantation stage. The serum β-human chorionic gonadotrophin （β-HCG） level 14 d after embryo transfer was measured,-ultrasound was performed 30 d after embryo transfer. The rates of biochemical pregnancy, clinical pregnancy, embryo implantation and early abortion were compared between groups. Results Totally 169 patients in control group and 160 patients in observation group completed the research. The biochemical pregnancy rate and clinical pregnancy rate in observation group were significantly higher than those in control group [52. 5% （84/160） vs 39. 6% （67/169）, 44. 4% （71/160） vs 33.7% （57/169） ] （P 〈0. 05） ; the embryo implantation rate and abortion rate were not significantly different between groups （P 〉 0. 05）. Conclusion Treatment with Chinese medical herbs of RKNAB and WKCF by stages can effectively promote embryo implantation and improve pregnant rate in IVF-ET.

关 键 词：不孕 体外受精-胚胎移植 补肾养血活血 温肾安胎 

分 类 号：R711.6[医药卫生—妇产科学]