慢性阻塞性肺疾病患者血清白介素-6降钙素原水平变化  

Chronic Obstructive Pulmonary Disease Patients with Serum Interleukin-6 Calcitionin Level Change

作　　者：赵小娟[1] 郭小亮 王晶[1] 侯永泉[1] 樊长娥[1] 

机构地区：[1]呼和浩特市第一医院呼吸二科,内蒙古呼和浩特010020 [2]内蒙古自治区人民医院神经内科,内蒙古呼和浩特010017

出　　处：《内蒙古医学杂志》2015年第11期1304-1306,共3页Inner Mongolia Medical Journal

摘　　要：目的探讨慢性阻塞性肺疾病(chronic obstructive pulmonary disease,COPD)患者血清白介素-6(interleukin-6,IL-6)、降钙素原(procalcitonin,PCT)的水平及其临床意义。方法收集正常对照组44例,慢性阻塞性肺疾病稳定者42例,慢性阻塞性肺病急性加重(acute exacerbation chronic obstructive pulmonary disease,AECOPD)54例,并测定血清IL-6、PCT含量。结果 (1)3组间血清IL-6含量有统计学意义;正常对照组、COPD稳定者与AECOPD相比,血清PCT水平有统计学意义,正常对照组与COPD稳定者血清PCT无统计学意义。(2)AECOPD患者与COPD稳定者痰培养阳性率有统计学意义。(3)COPD患者痰培养阳性者较阴性者IL-6、PCT水平有统计学意义。结论 PCT、IL-6可能共同参与了COPD急性发作,同时PCT可能与细菌感染有关。Objective To investigate the level and clinical significance of serum interleukin- 6 （IL- 6）and procalcitonin （PCT） in chronic obstructive pulmonary disease patients. Methods Collected 44 healthy people, 42 stable COPD patients and 54 AECOPD patients and tested the levels of serum IL - 6 and PCT. Results （1） There were significant difference in IL- 6 level among 3 groups; there was no significant difference in PCT level between control group and stable COPD patients, but compared with AECOPD patients there were significant difference. （2）The positive rate of sputum culture was significantly different between the patients of AECOPD and stable COPD. （3）The level of IL- 6 and PCT was significantly different between negative and positive pa- tients of sputum culture. Conclusion PCT and IL - 6 probably took part in the progression of AECOPD togeth- er , and there was correlation between PCT and bacterial infection.

关 键 词：慢性阻塞性肺病 白介素-6 降钙素原 

分 类 号：R563.8[医药卫生—呼吸系统]