慢性HBV感染者肝脏病理与ALT、性别及年龄等因素关系研究  

Correlation between liver pathology and ALT,gender and age in patients with chronic HBV infection

作　　者：李静[1] 阎纳新[1] 李昱晓[1] 吕颖[1] 路毓峰 孝奇[1] 尹书梅[1] 王瑜玲[1] 李兵顺[1] 

机构地区：[1]河北省石家庄市第五医院感染科,050021

出　　处：《传染病信息》2015年第6期372-374,共3页Infectious Disease Information

摘　　要：目的探讨慢性HBV感染者肝脏病理特征与ALT、性别、年龄和HBV DNA的相关性。方法选取282例慢性HBV感染者行肝脏穿刺病理检查,分别就炎症分级和肝纤维化分期与性别、年龄、ALT、HBV DNA水平的关系进行研究。结果 282例中炎症分级≥2级所占比例为58.51%,肝纤维化分期主要分布在S1（35.11%）和S2（34.75%）;不同炎症分级之间,性别差异无统计学意义;在年龄方面,G2~G4组均高于G0组（P坶〈0.05）;在ALT方面,G2~G4组均高于G0和G1组（P均〈0.05）,G4组高于G2和G3组（P均〈0.05）;不同炎症分级组HBV DNA水平差异无统计学意义。不同肝纤维化分期之间,患者性别分布方面S2组男性比例高于S3组（P〈0.05）;在年龄方面,S1、S2、S3组年龄依次升高（P均〈0.05）;ALT方面,S4组高于S0~S3组（P均〈0.05）;HBV DNA水平方面,S3组高于S1组（P〈0.05）,S4组高于S0~S3组（P均〈0.05）。结论慢性HBV感染者大部分炎症分级为G2以上,肝纤维化分期为S4以下。随着ALT升高,炎症分级和肝纤维化分期逐渐加重,但ALT≥2倍正常值上限后肝纤维化程度不再随之变化。男性患者肝纤维化程度较重。随着年龄增加肝脏炎症程度逐渐增加。Objective To investigate the correlation between hepatic pathological features and ALT,gender,age and HBV DNA in patients with chronic HBV infection.Methods Liver biopsy was conducted in 282 patients with chronic HBV infection.The correlation between inflammation grade and fibrosis stage and gender,age,ALT and HBV DNA were analyzed.Results Of 282 patients with chronic HBV infection,patients with inflammation grade more than or equal to 2 accounted for 58.51%;those with fibrosis stage 1（S1） and stage 2（S2） accounted for 35.11%and 34.75%,respectively.No significant difference in gender was found among patients with different inflammation grades.Patients with inflammation grade 2（G2）-grade 4（G4） were older than those with grade 0（G0）（P〈0.05）.ALT level of patients with G2-G4 was significantly higher than those of patients with G0 and grade 1（G1）（P〈0.05）,and the level of patients with G4 was significandy higher than those of patients with G2 and G3（P〈0.05）.HBV DNA level was not significantly different among patients with different inflammation grades.The proportion of male patients with S2 was significandy larger than that of male patients with S3（P〈0.05）.Patients with S1,S2 and S3 were older successively（P〈0.05）.ALT level of patients with S4 was significandy higher than those of patients with S0-S3（P〈0.05）.HBV DNA level of patients with S3 was significantly higher than that of patients with S1,and the level of patients with S4 was significantly higher than those of patients with S0-S3（P〈0.05）.Conclusions Most of the patients with chronic HBV infection have inflammatory grade more than or equal to G2 and liver fibrosis less than S4.With the increase of ALT,inflammation grade and fibrosis stage increase gradually,but they will not change when ALT is more than or equal to 2 times the upper limit of normal.Male patients have more severe fibrosis stage.The degree of liver inflammation gradually increases with age.

关 键 词：肝炎 乙型 慢性 肝纤维化 丙氨酸转氨酶 

分 类 号：R512.62[医药卫生—内科学]