接受高效抗反转录病毒治疗HIV感染者的巨细胞病毒性视网膜炎  

Cytomegalovirus retinitis in HIV-infected patients receiving highly active antiretroviral therapy

作　　者：穆薇薇[1] 孙鑫[1] 张福杰[1,2] 

机构地区：[1]中国疾病预防控制中心性病艾滋病预防控制中心治疗室,北京102206 [2]首都医科大学附属北京地坛医院感染科,100015

出　　处：《传染病信息》2015年第6期375-378,共4页Infectious Disease Information

基　　金：国家"十二五"科技重大专项(2012ZX10001004)

摘　　要：高效抗反转录病毒治疗(highly active antiretroviral therapy,HAART)出现以前,巨细胞病毒性视网膜炎的诊断属于AIDS终末期事件,通常发生在CD4^+T淋巴细胞<50/μl的HIV感染者中,诊断后的中位存活时间为6周~6个月。HAART的出现显著降低了巨细胞病毒性视网膜炎的发病率及AIDS患者病死率。但在发展中国家,由于缺乏常规筛查,巨细胞病毒性视网膜炎的发病率通常被低估,且普遍缺乏相关数据及管理策略。本文对近10年国内外免疫缺陷患者巨细胞病毒性视网膜炎的研究及发表数据进行回顾,提出应尽早开始HAART,并加强对严重免疫缺陷患者巨细胞病毒性视网膜炎进行筛查和早期诊断治疗的公共卫生策略。Before highly active antiretroviral therapy（HAART） era,the diagnosis of cytomegalovirus（CMV） retinitis is defined as a terminal stage event in AIDS patients.CMV retinitis usually occurs in HIV-infected patients with CD4~＋ T cells less than 50/μl.The median survival time is from 6 weeks to 6 months after being diagnosed with CMV retinitis.After HAART,the incidence of CMV retinitis and the mortality of AIDS patients decrease significantly.But in many developing countries,the incidence of CMV retinitis is underestimated due to lack of routine screening,and there is a lack of related data and disease management strategies as well.The authors review the related researches published in recent ten years in this field,highlight the importance of early initiation of HAART,and raise the public health concern of strengthening screening,and early diagnosis and treatment of CMV retinitis in HIV-infected patients with severe immunodeficiency.

关 键 词：获得性免疫缺陷综合征 抗逆转录病毒治疗 高效 巨细胞病毒视网膜炎 

分 类 号：R512.91[医药卫生—内科学]