基于声卡的CAPs阈值和调谐曲线的快速方法  

Fast CAPs threshold and tuning curves based on a sound card detection system

作　　者：宫琴[1] 张硕越 

机构地区：[1]清华大学生物医学工程系,北京100084

出　　处：《清华大学学报（自然科学版）》2015年第9期1036-1044,共9页Journal of Tsinghua University(Science and Technology)

基　　金：国家自然科学基金资助项目(61271133);教育部博导基金资助项目(20120002110054);清华信息科学与技术国家实验室(筹)学科交叉基金资助项目(042003172);深圳市科技计划项目(JCYJ20140827160046745)

摘　　要：听神经复合动作电位(CAPs)的阈值曲线和调谐曲线分别反映了听神经系统对刺激声的强度灵敏度和频率灵敏度。为快速、准确、客观地提取听神经系统的信息,该文基于多媒体外置声卡CAPs检测系统平台,使用C#语言设计了CAPs阈值曲线和调谐曲线的快速检测算法。并通过豚鼠实验,系统探讨了扫描方向、刺激声频率对快速CAPs调谐曲线的影响,并与传统测试方法得到结果进行比较,证明了快速测试方法的可靠性。该文还探讨了不同抑制准则、抑制声强度步长对于快速CAPs调谐曲线精确性的影响并验证了该系统的精确性。该系统为听神经复合动作电位的检测和后续研究提供了快速、客观、综合的分析研究平台。Auditory nerve compound action potentials（CAPs）threshold curves reflect the hearing sensitivity to intensity variations while its tuning curves reflect the sensitivity to frequency variations in the auditory nerve system.A fast CAPs threshold and tuning curve detection algorithm were developed based on an external multimedia sound card with C#to simplify the data extraction for studies of the auditory nerve system with more objective and more accurate information in a shorter time.The factors influencing the fast CAPs tuning curves such as the orientation of the sweeping frequency and the frequency of the stimulus were analyzed using guinea pig experiments.The fast CAPs threshold and tuning curves compare well with previous results.The factors contributing to fast CAPs tuning curve accuracy include reduction of the needed criteria and the rates of change for the masker intensity.This system is a fast,objective,and comprehensive analysis platform which will be valuable for further research on auditory nerve compound action potentials.

关 键 词：听神经复合动作电位(CAPs) 阈值曲线 调谐曲线 快速方法 

分 类 号：R318.6[医药卫生—生物医学工程]