γ干扰素诱导蛋白10对糖尿病合并活动性肺结核的辅助诊疗价值  

Clinical value of interferon-inducible protein-10 in diagnosis and treatment of diabetes and active tuberculosis

作　　者：何花[1] 周玉皆[2] 冯枭[1] 宋梅梅[1] 文高艳[1] 朱珠[1] 黄磊[1] 费贤树[1] 袁广琴 曾谊[1] 

机构地区：[1]南京市胸科医院鉴别诊断科,江苏南京210029 [2]南京市鼓楼医院呼吸科,江苏南京210008

出　　处：《东南大学学报（医学版）》2015年第6期916-918,共3页Journal of Southeast University(Medical Science Edition)

基　　金：2013年度南京市科技发展计划项目(2013sh352004)

摘　　要：目的:探讨γ干扰素诱导蛋白10(IP-10)对糖尿病合并活动性肺结核诊疗的临床价值。方法:选取糖尿病合并活动性肺结核患者10例、活动性肺结核患者34例、非结核肺部疾病患者10例、糖尿病患者10例及健康志愿者12例,检测血IP-10质量浓度,在抗结核治疗2个月后复测糖尿病合并活动性肺结核组血IP-10质量浓度,并进行统计分析。结果:糖尿病合并活动性肺结核组抗结核治疗前后的IP-10质量浓度分别为(410.35±121.36)、(270.11±94.25)ng·L-1,活动性肺结核组(195.61±70.71)ng·L-1,非结核肺部疾病组(106.27±52.34)ng·L-1,糖尿病组(112.77±32.47)ng·L-1,健康组(48.12±31.43)ng·L-1,糖尿病合并活动性肺结核组的IP-10质量浓度均高于其他4组,差异均有统计学意义(均P<0.01),糖尿病合并活动性肺结核组抗结核治疗2个月后血IP-10质量浓度低于抗结核治疗前,差异有统计学意义(P<0.01)。结论:糖尿病合并活动性肺结核患者血IP-10质量浓度明显升高,经抗结核治疗后下降,其可作为诊断及评估抗结核治疗疗效的辅助指标。Objective： To investigate the value of interferon-inducible protein-10（ IP-10） in clinical diagnosis and treatment of diabetes and active tuberculosis. Methods： 10 patients with diabetes and active tuberculosis,34 patients with active tuberculosis,10 patients with non-tuberculosis pulmonary disease,10 patients with diabetes,and 12 healthy volunteers were enrolled for serum IP-10 detection and statistical analysis. Serum IP-10 levels were re-examined in diabetes patients with active pulmonary tuberculosis who received anti-tuberculosis treatment for two months,and the statistical analysis was performed. Results： The serum IP-10 concentrations were（ 410. 35 ± 121. 36）,（ 195. 61 ±70. 71）,（ 106. 27 ± 52. 34）,（ 112. 77 ± 32. 47）,（ 48. 12 ± 31. 43）ng·L^-1 in diabetes and active tuberculosis group,active tuberculosis group,non-tuberculosis pulmonary disease group,diabetes group and healthy volunteers group,respectively. The serum IP-10 concentrations in patients with diabetes and active tuberculosis were significantly higher than the other 4 groups（ P〈0. 01）. Diabetes with active pulmonary tuberculosis patients exhibited decreased serum IP-10 levels after anti-tuberculosis treatment for two months（ P〈0. 01）. Conclusion： Serum IP-10 concentration increases in patients with diabetes and active tuberculosis,and decreases after anti-tuberculosis treatment. IP-10 could be used as an auxiliary index in the diagnosis and treatment of diabetes and active tuberculosis.

关 键 词：γ干扰素诱导蛋白10 肺结核 糖尿病 

分 类 号：R587.1[医药卫生—内分泌] R521[医药卫生—内科学]