两种剂量丙种免疫球蛋白对川崎病患儿冠状动脉病变及血清基质金属蛋白酶含量影响的比较  

Effect of different dose of intravenous immunoglobulin on treatment coronary lesion and serum gelatinase in Kawasaki disease

作　　者：闵锋[1] 朱少元 李娇春 

机构地区：[1]天门市第一人民医院儿科,湖北天门431700

出　　处：《东南大学学报（医学版）》2015年第6期942-945,共4页Journal of Southeast University(Medical Science Edition)

摘　　要：目的:探讨静脉注射丙种免疫球蛋白(intravenous immune globulin,IVIG)两种剂量对川崎病患儿冠状动脉病变(CAL)及血清基质金属蛋白酶(MMP)检测量的影响。方法:将128例川崎病患儿随机分为IVIG 1g·kg^(-1)组与IVIG 2 g·kg^(-1)组,分别予以相应剂量单次静脉注射,记录两组患儿总热程、退热时间、黏膜充血、手足肿胀和颈淋巴结肿大消退时间以及冠状动脉病变发生率。检测治疗前后两组患儿血清基质金属蛋白酶含量。结果:两组患儿的总热程、颈淋巴结肿大、手足肿胀、黏膜充血及发热消退时间等差异无统计学意义(P>0.05);IVIG 1 g·kg^(-1)组CAL发生率(15.62%)略高于IVIG 2 g·kg~(^(-1))组(14.06%),差异无统计学意义(P>0.05);治疗后两组患儿血清中基质金属蛋白酶-2与MMP-9较治疗前均明显减少,IVIG 1 g·kg^(-1)组MMP-2与MMP-9水平略高于IVIG 2 g·kg^(-1)组,但差异无统计学意义(P>0.05)。结论:1 g·kg^(-1)和2 g·kg^(-1)IVIG均可缩短川崎病病程,降低CAL发生率,减少血清中基质金属蛋白酶含量,减缓冠状动脉外细胞基质受损,但2 g·kg^(-1)的IVIG临床疗效略优,可能为治疗川崎病的有效剂量。Objective： To observe the effect of different dose of intravenous immunoglobulin on treatment coronary lesion and serum gelatinase in Kawasaki disease. Methods： 128 cases Kawasaki disease children were randomly divided into Group IVIG 1 g·kg^-1and Group IVIG 2 g·kg^-1,both groups were given single intravenous injection. Total fever duration,cervical lymph nodes,foot swelling,mucous congestion,fever subsiding time,and occurrence of coronary artery lesion（ CAL） of both groups were recorded. Serum gelatinase MMP-2 and MMP-9were detected. Results： There was no significant difference of total fever duration,cervical lymph nodes,foot swelling,mucous congestion,fever subsiding time in both groups（ P〉0. 05）. Occurrence of CAL in Group IVIG1 g·kg^-1 was slightly higher than that in Group IVIG 2 g·kg^-1（ P〉0. 05） with no significant difference; After treatment,MMP-2 and MMP-9 group reduced obviously,MMP-2 and MMP-9 in Group IVIG 1 g·kg^-1were slightly higher than that in Group IVIG 2 g·kg^-1（ P〉0. 05）. Conclusion： IVIG 1 g·kg^-1and IVIG 2 g·kg^-1can shorten the duration of Kawasaki disease,reduce the incidence of CAL,reduce serum gelatinase and coronary extracellular matrix damage,comparably IVIG 2 g·kg^-1is slightly more significantly effective,which may possibly be the effective dose for the treatment of Kawasaki disease.

关 键 词：丙种免疫球蛋白 川崎病 冠脉动脉病变 基质金属蛋白酶 

分 类 号：R726.199[医药卫生—儿科]