复方嗜酸乳杆菌治疗幽门螺杆菌感染的疗效观察  

Observation of Compound Lactobacillus Acidophilus in Treatment of Helicobacter Pylori Infection

作　　者：唐捷 龙云[1,2] 苏强 谭光林[3,2] 

机构地区：[1]南充市中心医院药剂科 [2]川北医学院第二临床医学院,四川南充637000 [3]南充市中心医院急诊科

出　　处：《中国医院用药评价与分析》2015年第9期1137-1139,共3页Evaluation and Analysis of Drug-use in Hospitals of China

基　　金：四川省卫生厅科研课题(No.120282)

摘　　要：目的:探讨复方嗜酸乳杆菌联合标准三联疗法治疗幽门螺杆菌感染性消化道溃疡的疗效和安全性。方法:选择2014年1—6月确诊为幽门螺杆菌感染的患者240例,按随机数字表法分为对照组和观察组,对照组112例患者给予传统的三联疗法(雷贝拉唑+阿莫西林+克拉霉素);观察组128例患者在传统三联疗法的基础上加用复方嗜酸乳杆菌,疗程均为14 d,观察患者的临床症状缓解率、溃疡愈合率、幽门螺杆菌根除率及不良反应。结果:治疗结束4周后,观察组与对照组患者的临床症状缓解率分别为90.62%(116/128)和76.79%(86/112);溃疡愈合率分别为92.19%(118/128)和74.11%(83/112);幽门螺杆菌根除率分别为91.62%(116/128)和73.21%(82/112);不良反应发生率分别为11.72%(15/128)、27.68%(31/112),2组的差异均有统计学意义(P<0.05)。结论:复方嗜酸乳杆菌联合三联疗法可显著提高幽门螺杆菌的根除率,促进溃疡愈合,降低不良反应,治疗效果较好,值得临床推广。OBJECTIVE： To investigate the efficacy and safety of compound lactobacillus acidophilus combined with standard triple therapy in treatment of helicobacter pylori infection gastrointestinal ulcer. METHODS： 240 cases of patients with helicobacter pylori infection admitted from Jan. to Jun. 2014 were divided into control group and observation group via random number table,with 112 cases in control group and 128 cases in observation group. The control group received conventional triple therapy（ rabeprazole azole,amoxicillin and clarithromycin）,the observation group additionally received compound lactobacillus acidophilus on the basis of traditional triple therapy. The treatment course were 14 d in two groups.The remission rate of clinical symptoms,healing rate of ulcer,Hp eradicate rate and adverse reactions were recorded in detail. RESULTS： After 4 weeks,as for the indexes in observation group and control group,the remission rate of clinical symptoms were 90. 62%（ 116 /128） and 76. 79%（ 86 /112）,respectively; healing rate of ulcer were 92. 19%（ 118 /128） and74. 11%（ 83 /112）,respectively; Hp eradicate rate were 91. 62%（ 116 /128） and 73. 21%（ 82 /112）,respectively;incidence of adverse reactions were 11. 72%（ 15 /128） and 27. 68%（ 31 /112）,respectively; the efficacy and adverse reactions in two groups were statistically significantly different（ P 0. 05）. CONCLUSIONS： Compound lactobacillus acidophilus combined with triple therapy can significantly improve the Hp eradicate rate,promote ulcer healing and reduce adverse reactions. The treatment effect is good,and worth clinical promotion.

关 键 词：复方嗜酸乳杆菌 幽门螺杆菌 消化道溃疡 三联疗法 疗效评价 

分 类 号：R975[医药卫生—药品]