糖皮质激素在阻止和治疗新生儿慢性肺损伤中的应用效果观察  

Application of Glucocorticoid in Prevention and Treatment of Neonatal Chronic Lung Injury

作　　者：金梅英[1] 罗忠媛 韩桂珍[1] 鲁丽[1] 潘晓会[1] 

机构地区：[1]吉林油田总医院儿科,吉林松原138000

出　　处：《中国医院用药评价与分析》2015年第9期1176-1178,共3页Evaluation and Analysis of Drug-use in Hospitals of China

摘　　要：目的:探讨糖皮质激素阻止和治疗新生儿慢性肺损伤中的临床治疗效果。方法:选取吉林油田总医院的120例慢性肺损伤早产儿,按随机数字表法分为观察组和对照组各60例,对照组患儿行持续通过机械通气氧气支持治疗,观察组患儿采用糖皮质激素治疗,比较2组的临床疗效、并发症等情况。结果:对照组患儿总有效率为25.00%(15/60),观察组患儿的总有效率为43.33%(26/60),差异有统计学意义(P<0.05);2组患儿脑出血发生率、脑室周围软化发生率、病死率的差异无统计学意义(P>0.05)。结论:糖皮质激素对新生儿慢性肺损伤的阻止及治疗效果较好,能缓解患儿的病情,促进患儿预后。OBJECTIVE： To study the clinic efficacy of application of glucocorticoid in prevention and treatment of neonatal chronic lung injury. METHODS： 120 cases of patients with chronic lung injury in Jilin Oil Field General Hospitalwere selected to be divided into observation group and control group via random number table,with 60 cases in each group. The control group received mechanical ventilation oxygen therapy,the observation group were treated with glucocorticoid,the clinical efficacy and complication were analyzed and compared in two groups. RESULTS： The total effective rate was 25. 00%（ 15 /60） in control group,and 43. 33%（ 26 /60） in observation group,there were statistically significant differences between two groups（ P 0. 05）. There was no significant difference in the incidence of cerebral hemorrhage,the incidence of periventircular encephalomalacia and the mortality in the 2 groups（ P 0. 05）.CONCLUSIONS： The clinic efficacy of application of glucocorticoid in prevention and treatment of neonatal chronic lung injury is effective,which can relief the pathogenetic conditions of the children and promote the prognosis.

关 键 词：新生儿慢性肺损伤 糖皮质激素 疗效 

分 类 号：R985[医药卫生—药品] R977.1[医药卫生—药学]