奥扎格雷钠和低分子肝素钙治疗糖尿病下肢动脉疾病的疗效  

Effect of Sodium Ozagrel and Low Molecular Heparin Calcium in the Treatment of Diabetes and Lower Extremity Arterial Disease

作　　者：丁广军[1] 

机构地区：[1]商丘市第一人民医院药学部,河南商丘476100

出　　处：《糖尿病新世界》2015年第22期1-3,共3页Diabetes New World Magazine

摘　　要：目的探究奥扎格雷钠和低分子肝素钙治疗糖尿病下肢动脉疾病的临床疗效。方法选取该院2013年3月—2014年10月收治的糖尿病下肢动脉疾病患者80例作为该次的研究对象,按照随机数字法将其分为两组,分别为实验组和常规组,实验组患者40例,常规组患者40例。其中对常规组患者给予低分子肝素钙治疗,实验组患者在上述治疗方法的基础上加用奥扎格雷钠联合治疗,比较两组糖尿病下肢动脉疾病患者的临床治疗效果、不良反应情况等。结果经过临床治疗后,实验组患者的总有效率为95.0%,常规组患者的总有效率为77.5%,实验组患者的总有效率明显高于常规组(P<0.05);治疗前后实验组患者各项生化指标的改善程度明显优于常规组(P<0.05);不良反应情况:实验组患者的不良反应发生率明显少于常规组(P<0.05)。结论对糖尿病下肢动脉疾病患者给予奥扎格雷钠联合低分子肝素钙治疗的临床效果显著,不良反应少,药物安全有效,对疾病治疗具有重要的指导意义。Objective To explore the clinical effect of sodium ozagrel and low molecular heparin calcium in the treatment of diabetes and lower extremity artery disease. Methods 80 cases with diabetes and lower extremity artery disease admitted in our hospital from March 2013 to October 2014 were selected as the subjects and divided into two groups, the experimental group and the control group with 40 cases in each according to the random number method. Patients in the control group were treated by low molecular heparin calcium, and those in the experimental group were treated by sodium ozagrel and low molecular heparin calcium. And the clinical effect and incidence of adverse reactions were compared between the two groups. Results After clinical treatment, the total effective rate of the experimental group was much higher than that of the control group（95.0% vs 77.5%）（P〈0.05）. The improvement of the biochemical indicators after treatment was significantly better in the experimental group than that in the control group （P〈0.05）. The incidence of adverse reactions was much lower in the experimental group than that in the control group（P〈0.05）. Conclusion For the treatment of diabetic patients with lower limb arterial disease, ozagrel sodium combined low molecular heparin calcium is of important guiding significance, it is safe and effective with remarkable clinical effect and less adverse reactions.

关 键 词：下肢动脉疾病 糖尿病 低分子肝素钙 奥扎格雷钠 

分 类 号：R4[医药卫生—临床医学]