除幽愈疡免煎颗粒抗消化性溃疡复发的临床研究  

The Clinical Study of Chuyou Yuyang Granules in Preventing Ulcer's Relapse

作　　者：杨芳[1] 葛桂萍[1] 喻海中[2] 

机构地区：[1]南通市中医院脾胃科,南通226000 [2]南通市中医院检验科,南通226000

出　　处：《世界中医药》2015年第12期1887-1889,1893,共4页World Chinese Medicine

基　　金：南通市科技局<除幽愈疡免煎颗粒抗消化性溃疡复发机制的临床与实验研究>(编号:HS2013053)

摘　　要：目的:探讨除幽愈疡免煎颗粒抗溃疡复发的机理。方法:将100例消化性溃疡患者随机分为西药组与中西医结合组,西药组给予奥美拉唑、克拉霉素和替硝唑三联疗法,中西医结合组加用除幽愈疡免煎颗粒,2组疗程均为6周,采用ELISA法检测并比较2组患者治疗前、后及治疗1年后血清VEGF、PGE2和b FGF水平及变化。结果:治疗6周后,2组患者治疗前和治疗后血清VEGF、PGE2和b FGF水平比较差异有统计学意义(P<0.05),治疗1年后,2组差值比较差异亦有统计学意义(P<0.05)。结论:除幽愈疡免煎颗粒在溃疡愈合过程中可能通过增加VEGF、PGE2及b FGF的表达,有效的提高了溃疡的愈合质量并有效的抗溃疡复发。Objective： To study the mechanism of Chuyou Yuyang Granules in preventing ulcer relapse. Methods： A total of 100 patients with peptic ulcer were randomly divided into western medicine group and integrated Chinese and western medicine group;the western medicine group was given omeprazole,amoxicillin and imidazole,while the other group were also given Chuyou Yuyang Granules on the basis of western medicine group＇s treatment. Both groups were treated for six weeks. Changes in serum VEGF,PGE2 and b FGF levels before and after the treatment of six weeks and a year were detected by ELISA methods. Results： After the treatment,significant differences in serum VEGF,PGE2 and b FGF levels were observed in both groups comparing with the levels before the treatment（ P〈0. 05）. Morever,after a year,changes were significantly different between the two groups（ P〈0. 05）.Conclusion： Chuyou Yuyang Granules may promote the expression of VEGF,b FGF and PGE2,which effectively improve the ulcer healing process.

关 键 词：除幽愈疡免煎颗粒 抗溃疡复发 

分 类 号：R285.6[医药卫生—中药学]