雷贝拉唑联合康复新液治疗酒精性胃黏膜损伤所致胃炎急性发作、胃黏膜溃疡的疗效观察  

Observation of Clinical Efficacy of Rabeprazole Combined with Kangfuxin Solution in Treatment of Acute Gastritis Attack and Gastric Ulcer Caused by Acute Alcoholic Gastric Injury

作　　者：张明娣[1] 时晓亚[2] 

机构地区：[1]东风汽车公司花果医院药剂科,湖北十堰442049 [2]东风公司总医院药剂科,湖北十堰442008

出　　处：《中国医院用药评价与分析》2015年第8期993-995,共3页Evaluation and Analysis of Drug-use in Hospitals of China

摘　　要：目的：探讨雷贝拉唑联合康复新液在控制酒精性胃黏膜损伤而引发的急性胃炎、消化性溃疡中黏膜修复的临床应用价值.方法：抽取某院消化内科2013年1月-2015年1月间收治的106例患者,按随机数字表法分为观察组和对照组各53例,对照组患者口服20 mg/d雷贝拉唑肠溶片,观察组在此基础上加服10 ml/次康复新液,2组患者均连续服用2-6周. 观察患者临床症状改善情况及胃黏膜愈合情况. 结果：治疗1周后,观察组患者上腹部疼痛、腹部不适等症状缓解程度明显优于对照组,差异有统计学意义（P〈0. 05）;治疗第4、12周后,观察组患者胃黏膜改善率为11. 32%（6/53）,对照组为33. 96%（18/53）,差异有统计学意义（P〈0. 05）;观察组患者的溃疡愈合率为75. 47%（40/53）,明显高于对照组的52. 83%（28/53）;观察组幽门杆菌根除率为83. 02%（44/53）,明显高于对照组的73. 58%（39/53）,差异均有统计学意义（P〈0. 05）. 结论：雷贝拉唑联合康复新液治疗酒精性胃黏膜损伤所致胃炎急性发作、胃黏膜溃疡,可迅速改善胃黏膜损伤,加快胃黏膜修复、愈合,疗效显著,值得临床推广.OBJECTIVE：To investigate the clinical application value of rabeprazole combined with kangfuxin solution in treatment of acute gastritis attack and gastric ulcer caused by acute alcoholic gastric injury. METHODS：106 cases from department of gastroenterology in a certain hospital from Jan. 2013 to Jan. 2015 were selected, according to random number table, they were divided into observation group and control group, with 53 cases in each group. The control group was treated with 20 mg/d rabeprazole Enteric-coated tablets;based on the control group, the observation group additionally received 10 ml/second kangfuxin solution,two groups of patients received the therapy for 2 to 6 weeks. The clinical improvement of symptoms, healing of gastric mucosa treatment were observed. RESULTS：After treatment of one week, relief degree of symptoms in respect of upper abdominal pain and abdominal discomfort in observation group were significantly higher than that in control group, with statistically significant difference（P〈0. 05）. After treatment of 12 weeks, the improvement rate of gastric mucosa was 11. 32%（ 6/53 ） in observation group, and 33. 96%（ 18/53 ） in control group, with statistically significant difference （ P 〈0. 05 ） . The ulcer healing rate was 75. 47%（ 40/53 ） in observation group, which was significantly higher than that in control group 52. 83%（28/53）;H. pylori eradication rate was 83. 02%（44/53） in observation group, which was significantly higher than that in control group 73. 58%（39/53）, with statistically significant difference （ P 〈0. 05 ） . CONCLUSIONS： The application of rabeprazole combined with kangfuxin solution in treatment of acute gastritis attack and gastric ulcer caused by acute alcoholic gastric injury can rapidly improve the gastric mucosal injury, accelerate the repair and healing of gastric mucosa with a significant effect, and it is worthy of further clinical promotion and application.

关 键 词：雷贝拉唑 胃黏膜损伤 急性发作 黏膜修复 

分 类 号：R975[医药卫生—药品]