培门冬酰胺酶与左旋门冬酰胺酶治疗儿童急性淋巴细胞白血病的疗效及不良反应观察  

Comparison of Efficacy and Adverse Reactions of L-asparaginase and Pegaspargase in Treatment of Children with Acute Lymphoblastic Leukemia

作　　者：程向东[1] 

机构地区：[1]孝感市中心医院总务科,湖北孝感432000

出　　处：《中国医院用药评价与分析》2015年第8期1009-1011,共3页Evaluation and Analysis of Drug-use in Hospitals of China

摘　　要：目的:探讨培门冬酰胺酶治疗急性淋巴细胞白血病的临床效果和安全性。方法:选取2012年7月—2015年1月孝感市中心医院收治的急性淋巴细胞白血病患儿148例作为研究对象,按随机数字表法分为对照组和观察组各74例,对照组患儿采用左旋门冬酰胺酶6 000 U/m2静脉滴注,每间隔1 d给药1次,维持8次;观察组患儿肌内注射2 500 U/m2培门冬酰胺酶,每间隔14 d注射1次,持续2次,比较2组的疗效及不良反应。结果:观察组患儿总有效率为97.30%(72/74),对照组患儿总有效率为94.60%(70/74),2组差异无统计学意义(P>0.05);2组患儿不良反应的差异亦无统计学意义(P>0.05)。结论:急性淋巴细胞白血病患儿行培门冬酰胺酶治疗,其效果与左旋门冬酰胺酶接近,且无明显不良反应,值得临床借鉴。OBJECTIVE：To probe into the clinical efficacy and safety of L-asparaginase and pegaspargase in treatment of children with acute lymphoblastic leukemia. METHODS： 148 cases with acute lymphoblastic leukemia admitted into Xiaogan Central Hospital from Jul. 2012 to Jan. 2015 were selected as the study object and were divided into the control group and the observation group according to the random number table, with 74 cases in each group. The control group received 6000 U/m2 L-asparaginase with IV drip, with intervals of 1 d for 1 time and last for 8 times;the observation group was treated with intramuscular injection of 2 500 U/m2 pegaspargase, with intervals of 14 d for 1 time and last for 2 times. The efficacy and adverse reactions were compared between two groups. RESULTS：The total effective rate of the observation group was 97. 30%（ 72/74 ） and the control group was 94. 60%（70/74）,there was no significant difference in two groups （P 〉0. 05）. To compare the adverse reactions in two groups, there was also no significant difference （ P〉0. 05 ） . CONCLUSIONS： The curative effect of pegaspargase in treatment of children with acute lymphoblastic leukemia is close to the effect of L-asparaginase,with no obvious adverse reactions, and it is worthy of actively clinical reference.

关 键 词：国产培门冬酰胺酶 儿童 初发急性淋巴细胞白血病 临床效果 

分 类 号：R979.1[医药卫生—药品]