1292张门诊超说明书用药处方分析  

Analysis of 1 292 Prescriptions for off-label Drug Use in Outpatient Department

作　　者：任智文[1] 陈鸣[1] 

机构地区：[1]四川省医学科学院.四川省人民医院药学部,四川成都610072

出　　处：《中国医院用药评价与分析》2015年第8期1099-1102,共4页Evaluation and Analysis of Drug-use in Hospitals of China

摘　　要：目的:了解四川省人民医院(以下简称"我院")门诊超说明书用药情况,为临床合理用药提供参考。方法:收集2014年1—6月我院门诊药房药师审核处方时发现的超说明书用药处方,共1 292张,对处方相关信息如患者性别、年龄、就诊科室、临床诊断和药品名称、规格、剂量、给药频次、给药途径等进行统计。以药品说明书为依据,对超说明书用药进行分类统计分析。结果:超说明书用药处方1 292张,占2014年1—6月门诊总处方数的0.22%。居前3位的超说明书用药问题分别为给药频次(585张,占45.28%)、给药剂量(496张,占38.39%)及给药途径(202张,占15.63%);居前3位的处方科室分别为专家门诊(325张,25.16%)、内科门诊(322张,24.92%)及外科门诊(167张,12.93%)。能提供用药依据的超说明书用药处方128张,仅占9.90%,多数超说明书用药处方不能提供相关用药依据。结论:超说明书用药情况较复杂,为保障患者用药安全及医师的合法权益,国家应尽快出台相关法规;医院应制订并不断完善相应的管理制度及流程,以规范超说明书用药的临床应用。OBJECTIVE：To investigate off-label drug use in outpatient department in People＇s Hospital of Sichuan province（ hereinafter referred to as ＂our hospital＂） , and to provide reference for the rational clinical of drug use. METHODS：1 292 prescriptions from Jan. to Jun. 2014 for off-label drug use were collected, which were found out during the verification by dispensing pharmacists in outpatient department. The relevant information of prescriptions such as patients＇ gender and age, the visit departments, clinical diagnosis, name of drug, specification of drug, dosage of drug, dosing frequency and route of administration were statistically analyzed. Based on the drug specification, the analysis of different categories toward off-label drug use was conducted. RESULTS：There were 1 292 prescriptions of off-label drug use, accounting for 0. 22% of all prescriptions from Jan. to Jun. 2014, in which off-label drug use in dosing frequency（45. 28%）, drug dosage（38. 39%）, administration route（15. 63%） occupied the top three of the off-label drug use problems. Also, the specialist outpatient（25. 16%）, the internal medicine department（24. 92%） and surgery department （ 12. 93%） occupied the top three of all the prescription departments. There were 128 prescriptions had evidence based medicine foundation, only accounting for 9. 90%, and most off-label drug use prescriptions cannot provide the relevant drug use evidence. CONCLUSIONS：The conditions of off-label drug use are complicated. In order to guarantee the medication safety of the patients and legitimate rights and interests of the doctors, the government should deliver the relevant laws and regulations as soon as possible, and the hospital should formulate and constantly improve the corresponding management system and process so as to regulate the clinical application of off-label drug use.

关 键 词：门诊 超说明书用药 处方分析 合理用药 

分 类 号：R95[医药卫生—药学] R97