不同服药方式抗结核固定剂量复合剂依从性调查  

Survey on compliance of different treatment way of fixed-dose combination drug of antituberculosis

作　　者：张今文[1] 张进国 李云飞[3] 李子国[4] 肖存[5] 梁晓雨 

机构地区：[1]北京中医药大学东方学院,河北廊坊065000 [2]易县疾病预防控制中心,河北易县074299 [3]保定市中心血站,河北保定071000 [4]涿州市医院,河北涿州072750 [5]易县医院,河北易县074299

出　　处：《医学研究与教育》2015年第6期25-29,共5页Medical Research and Education

基　　金："十二五"国家科技重大专项(2010ZX09102-301);保定市科学技术研究与发展计划项目(15ZF001)

摘　　要：目的了解不同服药方式抗结核固定剂量复合剂的依从性,为结核病防治提供科学依据。方法对初发肺结核患者采取每日服药方式（每日组,方案FDC-2HRZE/4HR）和隔日服药方式（隔日组,方案FDC-2H3R3Z3E3/4H3R3）治疗,采用统一问卷,对2种服药方式不同时期的依从性进行调查。结果每日组与隔日组比较,治疗前表示愿意接受6~8个月治疗的比例2组差异无统计学意义（χ~2=0.23,P〉0.05）,选择2种不同方式治疗的比例2组差异无统计学意义（χ~2=0.11,P〉0.05）;强化期末坚持遵医嘱服药的比例2组差异无统计学意义（χ~2=2.04,P〉0.05）,感觉药片太大的比例2组差异无统计学意义（χ~2=1.19,P〉0.05）,感觉药片太多的比例,隔日组大于每日组,2组差异有统计学意义（χ~2=6.35,P〈0.05）,感觉服药无困难的比例2组差异无统计学意义（χ~2=2.06,P〉0.05）,表示能坚持继续完成治疗的比例2组差异无统计学意义（χ~2=3.46,P〉0.05）;疗程末遵医嘱服药的比例2组差异无统计学意义（χ~2=1.56,P〉0.05）,服药感觉难受的比例2组差异无统计学意义（χ~2=1.31,P〉0.05）。结论每日服药和隔日服药2种不同服药方式服药依从性总体无明显差别,但2种服药方式认为药片太大的比例均较高、隔日服药方式认为药片太多的比例较高,故减小药片体积及减少服药片数是今后抗结核固定剂量复合剂改进的主要方向。Objective To learn about the compliance situation on different treatment ways with fixed dose combination drug of anti tuberculosis and provide a scientific basis for the prevention and control of tuberculosis. Methods The patients were received treatment with daily treatment way （Daily group, FDC-2HRZE/4HR） and the alternate day treatment way （Alternate day group, scheme was FDC-2H3R3Z3E3/4H3R3）, the compliance of daily treatment way and the alternate day treatment way with unified questionnaire were carried out. Results Compared with the daily treatment way and alternate day treatment way, there was no difference of the proportion of taking 6-8 months between two groups （X2=0.23, P〉0.05）, there was no difference of the proportion of two different treatment ways between two groups in before the treatment （X2=0.11, P〉0.05）; There was no difference of the proportion of follow the doctor＇s advice between two groups （X2=2.04, P〉0.05）, there was no difference of the proportion of feel tablets too big between two groups （X2=1.19, P〉0.05）, The proportion of feeling too many pills of alternate day treatment group was greater than that of daily treatment group, there was significant difference （X2=6.35, P〈0.05）, there was no difference of the proportion of feeling no difficulty in taking between two groups （X2=2.06, P〉0.05）, there was no difference of the proportion of representation can adhere continuing treatment between two groups in the end of strengthening period（X2=3.46, P〉0.05）; There was no difference of the proportion of follow the doctor＇s advice between two groups （X2=1.56, P〉0.05）, there was no difference of the proportion of feel uncomfortable taking the medicine between two groups by the end of treatment（X2=1.31, P〉0.05）. Conclusion There is no significant difference between two groups considering the treatment compliance situation of daily treatment way and the alternate day treatment way, however, the proportion of taking tablets too big is

关 键 词：肺结核 固定剂量复合剂 不同服药方式 依从性 调查 

分 类 号：R52[医药卫生—内科学]