合并睡眠呼吸暂停的中青年脑梗死患者颈动脉粥样硬化的研究  

Study of carotid atherosclerosis in middle-aged and young patients of cerebral infarction with sleep apnea-hypopnea

作　　者：赵慧新[1] 孟亚楠[1] 张杏红[1] 苏立凯[1] 甄景[1] 王杏微[1] 史福平[1] 

机构地区：[1]河北大学附属医院神经内科,河北保定071000

出　　处：《医学研究与教育》2015年第6期30-33,共4页Medical Research and Education

基　　金：河北省科学技术研究与发展计划项目(12276104D-81)

摘　　要：目的探讨合并睡眠呼吸暂停(sleep apnea-hypopnea,SA)的中青年脑梗死(cerebral infarction,CI)患者颈动脉粥样硬化(carotid atherosclerosis,CAS)情况。方法 80例中青年脑梗死患者分为单纯CI组(40例)、CI合并SA组(40例),两组患者均行颈动脉彩色多普勒超声检查,记录颈动脉内中膜厚度(intima-media thickness,IMT)及斑块情况。结果中青年CI合并SA组及单纯CI组患者颈动脉IMT分别为(1.335±0.219)mm、(1.088±0.202)mm,CI合并SA组高于单纯CI组(P<0.01),CI合并SA组及单纯CI组患者斑块发生率分别为75%、25%,CI合并SA组高于单纯CI组(P<0.01),CI合并SA组及单纯CI组患者不稳定斑块发生率分别为71%、30%,CI合并SA组高于单纯CI组(P<0.05)。结论中青年CI合并SA患者颈动脉粥样硬化程度更重。Objective To investigate the carotid atherosclerosis（CAS）in middle-aged and young patients of cerebral infarction （CI） with sleep apnea-hypopnea （SA）. Methods 80 middle-aged and young patients of CI were divided into two groups, only CI group （40 cases）） and CI combined with SA group （cases 40）.All patients were checked carotid artery through color doppler ultrasound and record intima-media thickness（IMT） and the state of plaques. Results The IMT of middle-aged and young patients in CI combined with SA group and in only CI group were （1.335±0.219）mm,（1.088±0.202）mm respectively, the degree of IMT in CI combined with SA group was significantly higher than that in only CI group （P〈0.01）.The rate of plaque occurrence in CI combined with SA group and in only CI group were 75%,25% respectively, the rate of plaque occurrence in CI combined with SA group was significantly higher than that in only CI group （P〈0.01）.The rate of unstable plaque occurrence in CI combined with SA group and in only CI group were 71%,30% respectively, the rate of unstable plaque occurrence in CI with SA group was significantly higher than that in only CI group （P〈0.05）. Conclusion There is higher degree of carotid artery atherosclerosis in the middle-aged and young patients of CI combined with SA group than that of only CI group.

关 键 词：脑梗死 睡眠呼吸暂停 颈动脉粥样硬化 中青年 

分 类 号：R5[医药卫生—内科学]