灰阶血流显像技术对阿托伐他汀治疗颈动脉粥样硬化的疗效评估  

Blood flow imaging technique in evaluation of efficacy of atorvastatin in treatment of carotid atherosclerosis

作　　者：陈礼波[1] 杨丹[1] 谭伟华[1] 张莉[1] 刘德英[1] 

机构地区：[1]解放军第三二四医院特诊科,重庆400020

出　　处：《临床军医杂志》2015年第5期502-504,共3页Clinical Journal of Medical Officers

摘　　要：目的运用灰阶血流显像(BFI)技术评估阿托伐他汀治疗颈动脉粥样硬化的疗效。方法选择2011年1月至2013年12月在我院诊治的120例动脉粥样硬化患者作为研究对象。按随机数字表法将其分为治疗组(60例)和对照组(60例),两组患者均给予常规治疗。治疗组每晚服用阿托伐他汀20 mg,对照组每晚服用相同剂量安慰剂(面粉)。两组治疗周期均为6个月。分别在治疗前及治疗后用超声的彩色多普勒血流显像(CDFI)技术和BFI技术对患者颈动脉进行检查,观察内中膜厚度(IMT)及斑块检出率。结果治疗后超声检查,治疗组IMT及斑块检出率较对照组减低,两组间比较,差异均有显著统计学意义(P<0.01);运用BFI技术后斑块检出率高于CDFI技术,两组间比较,差异有统计学意义(P<0.05)。结论阿托伐他汀对颈动脉粥样硬化的治疗效果确切,BFI技术为动脉粥样硬化的诊断提供了一种新的技术。Objective To evaluate the efficacy of atorvastatin in treatment of carotid atherosclerosis by blood flow imaging（ BFI）technique. Methods Patients（ n = 120） with carotid atherosclerosis admitted to our hospital from January 2011 to December 2013 were randomly divided into control group（ n = 60） and trial group（ n = 60）. All the patients were given routine therapy. The patients in the trial group were given atorvastatin（ 20 mg / d） besides the routine therapy and those in the control group were given placebos for6 months. Carotid intimal-medial thickness（ IMT） and plaque were examined by BFI and color Doppler flow imaging（ CDFI）before and after treatment. Results IMT and the number of carotid atherosclerotic plaque were significantly lower in the trial group than in the control group（ P〈0. 01）. The positively detected rate of plaque by BFI technique was higher than that by CDFI technique（ P〈0. 05）. Conclusion The efficacy of atorvastatin in treatment of carotid atherosclerosis is exact,and BFI technique provides a new technique to the diagnosis of atherosclerosis.

关 键 词：彩色多普勒血流超声显像 灰阶血流显像 阿托伐他汀 动脉粥样硬化 

分 类 号：R543.4[医药卫生—心血管疾病]