榆林地区妇女HPV感染基因型别分布和相关因素研究  

Analysis of HPV genotypes and related factors of healthy women in Yulin

作　　者：康伟[1,2] 高尚风[1] 高燕云[2] 张延玲[2] 

机构地区：[1]西安交通大学医学院第一附属医院妇产科,陕西西安710000 [2]榆林市第一医院,陕西榆林719000

出　　处：《延安大学学报（医学科学版）》2015年第4期14-17,共4页Journal of Yan'an University:Medical Science Edition

摘　　要：目的探索榆林地区妇女人乳头瘤病毒（humanpapillomavirus,HPV）感染基因亚型和影响HPV感染的相关因素。方法选取我院妇科2007-05-2013-05检查的妇女,采用巢式PCR和焦磷酸测序技术检测895例受检者宫颈脱落细胞中HPV分型情况,详细记录受检者一般资料,分析HPV感染的相关危险因素。结果 HPV阳性检出率为19.9%,共检出17种HPV亚型,以HPV16亚型检出率最高,HPV阳性感染率在各年龄段分布不同,差异有统计学意义（χ~2=16.89,P=0.02）,且随着年龄的增加,HPV感染率增加。未受过高等教育、吸烟、怀孕≥2次、性伴侣包皮过长、宫颈糜烂和宫颈炎症、经济收入≤3000、剖腹产、性生活频率〉2次/周HPV感染率高为HPV感染的相关因素。结论 HPVDNA基因型别检测可为宫颈癌的早期筛查,降低HPV感染率和宫颈相关疾病提供重要依据。Objective To analyze human papillomavirus（ HPV） genotypes and related factors of healthy women in Yulin. Methods Cervical exfoliated cells HPV genotypes of 895 casse of health examination in hour hospital from May 2007 to May 2013 in our hospital were examined with nest PCR and pyrosequencing methods. Besides,their general information was recorded and HPV infection related factors were analyzed. Results HPV infection positive rate was determined to be 19. 9%,and 17 kinds of genotypes were examined,among which HPV 16 was the highest one. In addition,HPV infection positive rate differed in different ages range,with significant difference（ X2= 16. 89,P = 0. 02） and it goes with age increasing. Having not been to university,smoking,being pregnant≥2 times,sexual partner with redundant prepuce,cervical erosion,cervicite,salary〈 3000 RMB / month,frequency of sexual activity〉 2 times / week will lead to high rate of HPV infection（ P〈0. 05 or 0. 01） and are all HPV related factors. Conclusion HPV DNA genotyping can provide important reference for HPV screening at early time and decrease the HPV infection rate and cervical disease.

关 键 词：人乳头瘤病毒 基因型 相关因素 年龄 

分 类 号：R711.74[医药卫生—妇产科学]