血清糖类抗原125水平在支气管扩张症患者中的临床意义  

Serum carbohydrate antigen-125 levels in patients with bronchiectasis

作　　者：顾靖华 邱宜军 陆亿华 徐旭东 徐志豪[2] 

机构地区：[1]舟山市普陀区人民医院呼吸科,浙江舟山316100 [2]浙江大学医学院附属第四医院,浙江义乌322000

出　　处：《浙江大学学报（医学版）》2015年第5期566-570,共5页Journal of Zhejiang University(Medical Sciences)

摘　　要：目的：探讨支气管扩张症患者中血清糖类抗原125（CA125）水平及其相关的影响因素。方法：收集2009年6月—2014年6月在浙江舟山市普陀区人民医院呼吸内科住院的504例支气管扩张症患者的临床资料，根据患者血清CA125水平分为CA125升高组和正常组，比较两组患者的年龄、性别以及白细胞、c反应蛋白（CRP）、血糖等指标的差异。其中CA125升高组患者治疗后予以复查，比较治疗前后血清CA125的水平差异，并进一步分析血清CA125的影响因素。结果：血清CA125升高组276例，其中男性117例，女性159例，平均年龄（66．31±13．13）岁，CA125平均水平为（83．70±43．87）U／mL；血清CA125正常组228例，男性84例，女性144例，平均年龄（67．54±10．50）岁，CA125平均水平为（20．68±9．67）U／mL。CA125升高组患者外周血白细胞计数为（10．08±5．68）×10^9／L，明显高于CA125正常组[（7．73±3．46）×10^9／L]，差异有统计学意义（P〈0．05）；CA125升高组患者外周血CRP中位数水平为22．98（3．18—196．88）mg／L，高于CA125正常组[6．34（0．50～97．66）mg／L]，差异有统计学意义（P〈0．05）。相关性分析结果表明，患者血清CA125水平与白细胞计数、CRP水平呈正相关（均19〈0．05），进一步多元逐步回归分析显示CRP水平是CA125的独立影响因素。支气管扩张症患者治疗前后血清CA125水平差异有统计学意义（P〈0．05）。结论：支气管扩张症患者血清CA125水平升高，经抗感染治疗后CA125水平下降，CRP水平是其独立影响因素。Objective： To evaluate the level of serum carbohydrate antigen-125 （CA125） and its related factors in patients with bronchiectasis. Methods： The clinical data of 504 patients with bronchiectasis in Zhejiang Putuo People＇s Hospital from June 2009 to June 2014 were collected in the study. The patients were divided into CA125 elevated group and CA125 normal group according to serum CA125 level, and the differences of serum CA125, age, gender, white blood cell （ WBC ） , C-reactive protein （CRP） , blood glucose and other test indicators were compared between two groups. Results： There were 276 patients including 117 male and 159 female with elevated serum CA125. Their mean age was （66.3± 13.1 ） years and the mean level of CA125 was （83.70 ± 43.87 ） U/mL. There were 228 patients including 84 male and 144 female with normal CA125 levels. Their mean age was （ 67.5 ± 10.5 ） years and the mean level of CA125 was （20. 68 ± 9. 67）U/mL. The peripheral blood WBC in patients with CA125 elevated group [ （ 10.08 ± 5.68 ）×10^9/L] was significantly higher than that in CA125 normal group[7.73 ±3.46） ×10^9/L], the difference was statistically significant （P〈0.05）. The medium of CRP level in patients with CA125 elevated group[ 22.98 （3.18 ± 196. 88）mg/L] was significantly higher than that in CA125 normal group [ 6. 34 （0.50 ± 97.66 ） mg/L ] （ P 〈 0. 05 ）. Correlation analysis showed that CA125 was positively correlated with WBC and CRP （P 〈 0. 05 ）. Stepwise regression analysis showed that CRP was the only independent prognostic factors of CA125. Paired t test showed the presence of CA125 serum in patients with bronchiectasis had a significant difference between before and after anti-infection therapy（P 〈 0. 05）. Conclusion： The serum levels of CA125 rise in patients with bronchiectasis, while it decrease after anti-infection therapy. CRP is an independent associated factor of serum CA125 level.

关 键 词：支气管扩张症 CA125抗原/血液 C反应蛋白质 

分 类 号：R562.22[医药卫生—呼吸系统]