弥散张量成像技术在青光眼中枢神经系统改变研究中的应用  

Application of diffusion tensor imaging in central nervous system changes induced by glaucoma

作　　者：赵晋[1] 张宇燕[1] 

机构地区：[1]复旦大学附属华山医院眼科,上海200040

出　　处：《国际眼科纵览》2015年第6期381-385,共5页International Review of Ophthalmology

摘　　要：青光眼中枢神经系统的改变近年来受到重视.功能磁共振技术中的弥散张量成像（diffusion tensor image,DTI）技术作为一种无创而有效的神经纤维示踪方法,能敏感地评估脑组织的显微结构以及神经病变的病理改变,现已被应用于青光眼中枢神经系统研究的各个方面,包括视神经、外侧膝状体、视放射、脑容积等中枢神经系统部分以及不同类型青光眼的鉴别诊断.DTI的优势是可以反映神经功能的改变,但存在分辨率不足,扫描中易受复杂神经纤维走向的干扰等劣势,限制了其在临床中的应用.目前DTI技术只限于科学研究,今后在眼科学领域会有更广泛的应用.The damage of the central nervous system in glaucoma have drawn great attention of the researchers recently.As one of functional magnetic resonance imaging （fMRI）, the diffusion tensor image （DTI） technique can non-invasively and effectively trace the nerve fibers.It can also sensitively evaluate the micro-structure of brain tissues and the pathological changes of nerve fibers.It is applied into every aspect of glaucoma research, and already led to some achievements in researches about optic nerve, lateral geniculate body, optic radiation, brain volume and differential diagnosis of different types of glaucoma.As a new tool,the advantage of DTI includes displaying the functionality change of nerve fiber, and the disadvantage is the low resolution and susceptibility to the trend of complicated nerve fibers.At present DTI is only applied in medical research, in the future it will be widerly used in the ophthalmological field.

关 键 词：青光眼 中枢神经 弥散张量成像 

分 类 号：R445.2[医药卫生—影像医学与核医学]